File:Steroidogenesis ja.svg

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日本語: この図はヒトのステロイドホルモン生成における酵素と酵素が存在する細胞器官、基質ならびに生成物の全体図である。またこの図は（コレステロールから）プロゲステロン、鉱質コルチコイド、糖質コルチコイド、そしてアンドロゲンおよびエストロゲンに至る主要なステロイドを記述している。

図に示すとおりそれぞれ（生合成の過程で）オーバーラップするものである。 図中、白い円で囲んだところは基質と比較した分子構造の変化した箇所を示す。

なお、HSD は、ヒドロキシステロイドデヒドロゲナーゼを表す。
English: Enzymes, their cellular location, substrates and products in human steroidogenesis.

Shown also is the major classes of steroid hormones: progestagens, mineralocorticoids, glucocorticoids, androgens and estrogens. However, they partly overlap, e.g. mineralocorticoids and glucocorticoids.

White circles indicate changes in molecular structure compared with precursors. For more information on interpretation of molecular structures, see Wikipedia:structural formula.

HSD: Hydroxysteroid dehydrogenase

References:

  • Boron WF, Boulpaep EL (2003) Medical Physiology: A Cellular And Molecular Approach, Elsevier/Saunders, pp. page 1,300 ISBN: 1-4160-2328-3.
  • For the absence of conversion of corticosterone to cortisol: Steroid hormone biosynthesis Reference pathway (KO). KEGG: Kyoto Encyclopedia of Genes and Genomes. Kyoto University Bioinformatics Center. (1 November 2013).
There is no appreciable conversion of corticosterone to cortisol in the adrenal cortex as 21-OH steroids are poor substrates for 17-alpha hydroxylase.

Further reading:

  • Hanukoglu I (1992). "Steroidogenic enzymes: structure, function, and role in regulation of steroid hormone biosynthesis". The Journal of Steroid Biochemistry and Molecular Biology 43 (8): 779–804. DOI:10.1016/0960-0760(92)90307-5. PMID 22217824.
  • Payne AH, Hales DB (2004). "Overview of steroidogenic enzymes in the pathway from cholesterol to active steroid hormones". Endocrine Reviews 25 (6): 947–70. DOI:10.1210/er.2003-0030. PMID 15583024.

See also:

Date
Source https://upload.wikimedia.org/wikipedia/commons/1/13/Steroidogenesis.svg (Original SVG file as of 2013/3/13(wed) 15:12), Häggström M, Richfield D (2014). "Diagram of the pathways of human steroidogenesis". WikiJournal of Medicine 1 (1). DOI:10.15347/wjm/2014.005. ISSN 20024436.
Author Translation into Japanese by User:にょろん based on the version by David Richfield (User:Slashme) and Mikael Häggström. Derived from previous version by Hoffmeier and Settersr.

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