File:Molecular-dynamics-simulations-highlight-structural-and-functional-alterations-in-deafness-related-Movie3.ogv

English: Effect of pulling one NTH toward the center of the pore. The pulled helix is colored in red, while the other NTHs in blue. The initial position is shown as a reference in white. The pulling of a helix in the wild type (on the left) and in the mutant (on the right) reveals different qualitative behaviors, in addition to the quantitative differences described in Figure 6. While in the wild type hemichannel the pulled helix moves abruptly at the end of the simulation, for the mutant this motion occurs earlier, but is then hampered by the interaction of the pulled helix with a neighboring NTH which are more mobile and do not keep the symmetric configuration of the wild type.