File:Induced-Effects-of-Sodium-Ions-on-Dopaminergic-G-Protein-Coupled-Receptors-pcbi.1000884.s002.ogv

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Induced-Effects-of-Sodium-Ions-on-Dopaminergic-G-Protein-Coupled-Receptors-pcbi.1000884.s002.ogv ‎(Ogg Theora video file, length 55 s, 537 × 546 pixels, 4.02 Mbps, file size: 26.19 MB)

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English: A 1.1 µs long-time MD simulation demonstrates that a sodium ion spontaneously penetrates the dopaminergic D2 receptor from the extracellular side. Once inside the receptor, the sodium ion provokes a conformational change of the rotamer switch Trp6.48. Moreover, in the presence of a sodium ion site c (below the rotamer switch Trp6.48), a second sodium ion is able to enter at times the D2 receptor where it occupies the orthosteric site a (above the rotamer switch Trp6.48).
Date
Source Video S1 from Selent J, Sanz F, Pastor M, De Fabritiis G (2010). "Induced Effects of Sodium Ions on Dopaminergic G-Protein Coupled Receptors". PLOS Computational Biology. DOI:10.1371/journal.pcbi.1000884. PMID 20711351. PMC: 2920834.
Author Selent J, Sanz F, Pastor M, De Fabritiis G
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This file was transferred to Wikimedia Commons from PubMed Central by way of the Open Access Media Importer.
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Date/TimeThumbnailDimensionsUserComment
current00:24, 14 November 201255 s, 537 × 546 (26.19 MB)Open Access Media Importer Bot (talk | contribs)Automatically uploaded media file from Open Access source. Please report problems or suggestions here.

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Format Bitrate Download Status Encode time
VP9 480P 1.27 Mbps Completed 18:39, 29 August 2018 1 min 37 s
Streaming 480p (VP9) 1.27 Mbps Completed 12:44, 23 March 2024 1.0 s
VP9 360P 639 kbps Completed 18:39, 29 August 2018 1 min 36 s
Streaming 360p (VP9) Not ready Unknown status
VP9 240P 320 kbps Completed 18:39, 29 August 2018 58 s
Streaming 240p (VP9) 320 kbps Completed 10:07, 5 December 2023 1.0 s
WebM 360P 495 kbps Completed 17:07, 15 November 2012 1 min 7 s
Streaming 144p (MJPEG) 850 kbps Completed 13:45, 15 November 2023 2.0 s

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