File:In-Vitro-and-In-Vivo-Anti-Schistosomal-Activity-of-the-Alkylphospholipid-Analog-Edelfosine-pone.0109431.s004.ogv

English: In vitro effects following edelfosine treatment on S. mansoni adult worms. Untreated control group (Live) shows no alteration in morphology and was able to produce eggs. Dead worms following heating at 56°C or treatment with 10 µM praziquantel (PZQ) (positive controls) showed no motility and became nontranslucent. Worms treated with the indicated concentrations of edelfosine (EDLF) for 48 h, 72 h and 168 h showed toxic actions when used ≥ 10 µM. In the video one arrow shows severely dilated gut of a female worm and two arrows show extensive damage on the tegument of a male worm following treatment with 30 µM of EDLF for 48 h. After the 4:30 min, another arrow shows extensive peeling in the tegument of a female worm treated with 10 µM EDLF for 168 h.