File:Identification-of-Injury-Specific-Proteins-in-a-Cell-Culture-Model-of-Traumatic-Brain-Injury-pone.0055983.s006.ogv
Identification-of-Injury-Specific-Proteins-in-a-Cell-Culture-Model-of-Traumatic-Brain-Injury-pone.0055983.s006.ogv (Ogg multiplexed audio/video file, Theora/Vorbis, length 21 s, 640 × 360 pixels, 1.03 Mbps overall, file size: 2.56 MB)
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DescriptionIdentification-of-Injury-Specific-Proteins-in-a-Cell-Culture-Model-of-Traumatic-Brain-Injury-pone.0055983.s006.ogv |
English: Injury induces proliferation and migration towards the cut in neuronal cells. Neurons, recognized by their round to oval somal shape and their extending axon and dendrites, migrate towards and along the cut. They also proliferate at a higher ratio compared to neurons in an uninjured culture. One should note, though, that although expressing the neuronal marker βIII tubulin, the cells are not completely mature. The astrocytes are recognized by their round cell nuclei and often highly vacuolized appearance and are frequently covered in dead cells and debris. They extend numerous lamellipodia towards the laceration, but do not actively migrate towards it. Astrocytes are not induced to proliferate in response to injury in comparison to the neurons. Oligodendrocytes are few and harder to recognize, but are neither induced to migrate nor do they proliferate. Films are composed at 7 frames per second with images taken every 10 minutes for 24 h. |
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Source | Video S1 from Loov C, Shevchenko G, Geeyarpuram Nadadhur A, Clausen F, Hillered L, Wetterhall M, Erlandsson A (2013). "Identification of Injury Specific Proteins in a Cell Culture Model of Traumatic Brain Injury". PLOS ONE. DOI:10.1371/journal.pone.0055983. PMID 23409102. PMC: 3567017. | ||
Author | Loov C, Shevchenko G, Geeyarpuram Nadadhur A, Clausen F, Hillered L, Wetterhall M, Erlandsson A | ||
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current | 22:46, 26 February 2013 | 21 s, 640 × 360 (2.56 MB) | Open Access Media Importer Bot (talk | contribs) | Automatically uploaded media file from Open Access source. Please report problems or suggestions here. |
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Author | Loov C, Shevchenko G, Geeyarpuram Nadadhur A, Clausen F, Hillered L, Wetterhall M, Erlandsson A |
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Usage terms | http://creativecommons.org/licenses/by/3.0/ |
Image title | Injury induces proliferation and migration towards the cut in neuronal cells. Neurons, recognized by their round to oval somal shape and their extending axon and dendrites, migrate towards and along the cut. They also proliferate at a higher ratio compared to neurons in an uninjured culture. One should note, though, that although expressing the neuronal marker ?III tubulin, the cells are not completely mature. The astrocytes are recognized by their round cell nuclei and often highly vacuolized appearance and are frequently covered in dead cells and debris. They extend numerous lamellipodia towards the laceration, but do not actively migrate towards it. Astrocytes are not induced to proliferate in response to injury in comparison to the neurons. Oligodendrocytes are few and harder to recognize, but are neither induced to migrate nor do they proliferate. Films are composed at 7 frames per second with images taken every 10 minutes for 24 h. |
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Date and time of digitizing | 2013 |
- Videos of developmental biology
- Videos of stem cells
- Neural stem cells
- Cell differentiation
- Cell fate determination
- Molecular cell biology
- Cell anatomy
- Videos of cell types
- Cell death
- Cell division
- Cell growth
- Cellular stress responses
- Cellular neuroscience
- Molecular neuroscience
- Spectrometric identification of proteins
- Media from PLOS ONE