File:Effect of experimental hookworm infection on insulin resistance in people at risk of type 2 diabetes.pdf
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[edit]DescriptionEffect of experimental hookworm infection on insulin resistance in people at risk of type 2 diabetes.pdf |
English: The reduced prevalence of insulin resistance and type 2 diabetes in countries with endemic parasitic worm infections suggests a protective role for worms against metabolic disorders, however clinical evidence has been non-existent. This 2-year randomised, double-blinded clinical trial in Australia of hookworm infection in 40 male and female adults at risk of type 2 diabetes assessed the safety and potential metabolic benefits of treatment with either 20 (n = 14) or 40 (n = 13) Necator americanus larvae (L3) or Placebo (n = 13) (Registration ACTRN12617000818336). Primary outcome was safety defined by adverse events and completion rate. Homoeostatic model assessment of insulin resistance, fasting blood glucose and body mass were key secondary outcomes. Adverse events were more frequent in hookworm-treated participants, where 44% experienced expected gastrointestinal symptoms, but completion rates were comparable to Placebo. Fasting glucose and insulin resistance were lowered in both hookworm-treated groups at 1 year, and body mass was reduced after L3-20 treatment at 2 years. This study suggests hookworm infection is safe in people at risk of type 2 diabetes and associated with improved insulin resistance, warranting further exploration of the benefits of hookworms on metabolic health. |
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Source | https://www.nature.com/articles/s41467-023-40263-4 |
Author | Doris R. Pierce, Malcolm McDonald, Lea Merone, Luke Becker, Fintan Thompson, Chris Lewis, Rachael Y. M. Ryan, Sze Fui Hii, Patsy A. Zendejas-Heredia, Rebecca J. Traub, Matthew A. Field, Tony Rahman, John Croese, Alex Loukas, Robyn McDermott & Paul R. Giacomin |
doi:10.1038/s41467-023-40263-4
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current | 16:12, 25 August 2023 | 1,239 × 1,645, 11 pages (2.11 MB) | Koavf (talk | contribs) | Uploaded a work by Doris R. Pierce, Malcolm McDonald, Lea Merone, Luke Becker, Fintan Thompson, Chris Lewis, Rachael Y. M. Ryan, Sze Fui Hii, Patsy A. Zendejas-Heredia, Rebecca J. Traub, Matthew A. Field, Tony Rahman, John Croese, Alex Loukas, Robyn McDermott & Paul R. Giacomin from https://www.nature.com/articles/s41467-023-40263-4 with UploadWizard |
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Publisher | Springer US |
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Software used | Springer |
File change date and time | 21:30, 26 July 2023 |
Date and time of digitizing | 22:46, 26 July 2023 |
Date metadata was last modified | 21:30, 26 July 2023 |
Copyright status | Copyrighted |
Identifier | doi:10.1038/s41467-023-40263-4 |
Conversion program | iText® 5.3.5 ©2000-2012 1T3XT BVBA (SPRINGER SBM; licensed version) |
Encrypted | no |
Page size | 595.276 x 790.866 pts |
Version of PDF format | 1.4 |