File:Effect of Transforming Growth Factor Beta (TGF Beta) and Vitamin D3 Metabolites on Protein Kinase C Mediated Signal Transduction in Rat Costochondral Chondrocyte Cultures. (IA effectoftransfor1094510805).pdf
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Summary[edit]
Effect of Transforming Growth Factor Beta (TGF Beta) and Vitamin D3 Metabolites on Protein Kinase C Mediated Signal Transduction in Rat Costochondral Chondrocyte Cultures.
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| Author |
Mackey, Scott A. |
| Title |
Effect of Transforming Growth Factor Beta (TGF Beta) and Vitamin D3 Metabolites on Protein Kinase C Mediated Signal Transduction in Rat Costochondral Chondrocyte Cultures. |
| Description |
It is Imown that vitamin D3 metabolites and transforming growth factor % (TOF-J3) regulate proliferation and differentiation of chondrocytes isolated from the growth zone or resting zone of rat costochondral cartilage. It was hypothesized that both TGF-% and the vitamin D metabolites play a role in signal transduction in the rat costochondral chondrocyte model and that the regulation of protein kinase C by these metabolites would be cell maturation- dependent. Confluent, fourth passage cultures of growth zone and resting zone chondrocytes were treated with vitamin D3 metabolites for up to 24 hours, lysed, and the cell extracts assayed for protein kinase C (PKC) specific activity using a specific peptide substrate. The addition of i,25-(OH)2D3 to growth zone chondrocyte cultures resulted in a rapid, dose dependent stimulation of PKC specific activity. Subjects: |
| Language | English |
| Publication date | December 2002 |
| Current location |
IA Collections: navalpostgraduateschoollibrary; fedlink |
| Accession number |
effectoftransfor1094510805 |
| Source | |
| Permission (Reusing this file) |
This publication is a work of the U.S. Government as defined in Title 17, United States Code, Section 101. As such, it is in the public domain, and under the provisions of Title 17, United States Code, Section 105, may not be copyrighted. |
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| Date/Time | Thumbnail | Dimensions | User | Comment | |
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| current | 12:42, 18 July 2020 |  | 1,275 × 1,650, 104 pages (3.19 MB) | Fæ (talk | contribs) | FEDLINK - United States Federal Collection effectoftransfor1094510805 (User talk:Fæ/IA books#Fork8) (batch 1993-2020 #14758) |
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