File:Allosteric-Communication-in-Myosin-V-From-Small-Conformational-Changes-to-Large-Directed-Movements-pcbi.1000129.s002.ogv

English: The NMSM rearrangement of the P-loop and switch I. The movie shows the rigor to post-rigor rearrangement of the P-loop and switch I nucleotide-binding elements as described by the optimal superposition of the 40 lowest-frequency rigor modes. The rigor (thick tube) and the post-rigor (thin tube) structures with the N-terminal subdomain aligned are shown in colors and grey, respectively. The ATP molecule in the post-rigor structure is shown in white as a stick representation. The color code is as follows: the N and U50 subdomains are colored in orange and blue; the P-loop, switch I, and switch II linkers are colored in cyan, magenta and yellow, respectively. The movie shows the way switch I approaches the P-loop and moves “over” it to coordinate the nucleotide.