File:Adhesion-Failures-Determine-the-Pattern-of-Choroidal-Neovascularization-in-the-Eye-A-Computer-pcbi.1002440.s021.ogv

English: Time-Series of a Simulation Replica Exhibiting Sub-Retinal CNV to Sub-RPE CNV Progression (P23 CNV). 3D visualization of a simulation replica forming P23 CNV in one simulated year ( RRl  =1, RRp  = 1, RBl = 1, RBp  = 1, ROl  = 1) (adhesion scenario ID: 108, simulation ID: 1080). Stalk cells invade the sub-retinal space through the hole in BrM that the tip cell form during the first 24 hours of the simulation and form a fully developed sub-retinal capillary network by month 1. Only a few stalk cells , mostly near the hole in BrM , invade the sub-RPE space during the first month . Additional stalk cells invade the sub-RPE space by month 6, disrupting the RPE and causing a micro-tear. The POS contacts BrM at the location of the RPE tear. Cell type colors: 1) POS and PIS : light purple, 2) RPE : brown, 3) Stalk cells : green ( stalk cells in the sub-retinal space have lighter shading), 4) Vascular cells ( CC ): red, 5) BrM : light blue. We have rendered the boundaries of individual cells as semi-transparent membranes. POS , PIS and RPE cells are more transparent to show the underlying structures. (AVI)