File:Adhesion-Failures-Determine-the-Pattern-of-Choroidal-Neovascularization-in-the-Eye-A-Computer-pcbi.1002440.s017.ogv

English: Time-Series of a Simulation Replica with Stable Type 1 CNV. 3D visualization of a simulation replica exhibiting Stable Type 1 CNV over one simulated year (adhesion scenario ID: 38, simulation ID: 902) (RRl = 3, RRp = 3, RBl = 2, RBp = 2, ROl = 3). Stalk cells invade the sub-RPE space through a hole in BrM that the tip cell opens during the first 24 hours. Stalk cells proliferate until they fill the sub-RPE space in month 9, after which proliferation slows down. The 45 stalk cells form a connected capillary network in the sub-RPE space. Cell type colors: 1) POS and PIS: light purple, 2) RPE: brown, 3) Stalk cells: green, 4) Vascular cells (CC): red, 5) BrM: light blue. We have rendered the boundaries of individual cells as semi-transparent membranes. POS, PIS and RPE cells are more transparent to show the underlying structures.