File:A-Validated-Multiscale-In-Silico-Model-for-Mechano-sensitive-Tumour-Angiogenesis-and-Growth-pcbi.1005259.s008.ogv

English: Tumour growth and angiogenesis animation that illustrates the capillary radius dynamics. Visualisation of the tumour growth and angiogenesis model predictions, over a period of 40 days, where the tumour is shown as a transparent object and the blood vessels are rendered as tubes, thus, depicting the adaptive behaviour to capillaries to the mechanical stimuli (i.e. fluid viscous forces and solid stresses). The colour contour on the vascular network represents the vessel radius, in μm. Since vessel wall remodelling is modulated by the local flow WSS magnitude, note the direct correlation of the radius development with respect to the WSS in S3 Video. Note also that some parent vessels (originally shown white) are compressed due to the local increase of the mechanical forces, while others during the course of the analysis are collapsed and hence vanish from the network. Finally, note the formation of vascular shunts at the top left and inferior of the tumour, and the pronounced tortuosity of the newly formed vessels in the the peri-tumoural area.