File:Type-I-Interferon-Programs-Innate-Myeloid-Dynamics-and-Gene-Expression-in-the-Virally-Infected-ppat.1003395.s006.ogv
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[edit]DescriptionType-I-Interferon-Programs-Innate-Myeloid-Dynamics-and-Gene-Expression-in-the-Virally-Infected-ppat.1003395.s006.ogv |
English: IFN-I signaling deficiency completely abolishes microglial activation and dynamics following infection. Representative time lapses of 3D reconstructions show the dynamics of CX3CR1-GFP+/− labeled myeloid cells (green) captured in a wild type (left) vs. a IFN-I receptor deficient (right) OT-I CX3CR1-GFP+/− mouse at day 15 post-infection. The maximal projections represent z-stacks (50 µm in depth) imaged over a 52 min time period. Blood vessels are shown in red. Note that microglia in the infected IFN-IR−/− mouse remain non-activated and highly ramified when compared to the wild type control. |
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Source | Movie S4 from Nayak D, Johnson K, Heydari S, Roth T, Zinselmeyer B, McGavern D (2013). "Type I Interferon Programs Innate Myeloid Dynamics and Gene Expression in the Virally Infected Nervous System". PLOS Pathogens. DOI:10.1371/journal.ppat.1003395. PMID 23737750. PMC: 3667771. | ||
Author | Nayak D, Johnson K, Heydari S, Roth T, Zinselmeyer B, McGavern D | ||
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Date/Time | Thumbnail | Dimensions | User | Comment | |
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current | 01:50, 13 June 2013 | 3.5 s, 1,000 × 600 (4.86 MB) | Open Access Media Importer Bot (talk | contribs) | Automatically uploaded media file from Open Access source. Please report problems or suggestions here. |
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Author | Nayak D, Johnson K, Heydari S, Roth T, Zinselmeyer B, McGavern D |
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Usage terms | http://creativecommons.org/publicdomain/zero/1.0/ |
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Software used | Xiph.Org libtheora 1.1 20090822 (Thusnelda) |
Date and time of digitizing | 2013-05 |