File:The-Kinematics-of-Cytotoxic-Lymphocytes-Influence-Their-Ability-to-Kill-Target-Cells-pone.0095248.s001.ogv
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The-Kinematics-of-Cytotoxic-Lymphocytes-Influence-Their-Ability-to-Kill-Target-Cells-pone.0095248.s001.ogv (Ogg Theora video file, length 25 s, 550 × 550 pixels, 585 kbps, file size: 1.77 MB)
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[edit]DescriptionThe-Kinematics-of-Cytotoxic-Lymphocytes-Influence-Their-Ability-to-Kill-Target-Cells-pone.0095248.s001.ogv |
English: CD8+ T cells require direct prolonged contact with target cells to kill KC CD8+ T cells were loaded with SIINFEKL and incubated with effector CD8+ T cells from EGFP+OT-1 mice. Images were taken by confocal microscopy every 12 minutes in 2 µm Z-sections and have been shown here as maximal intensity projections. Cell permeable indicator dye in the media fluoresces red upon activation of caspase-3. Effector cells are seen to attach to KC early in the incubation period. KC death is seen at 21 hours by colour change as caspase-3 is activated, and then by blebbing. Target cell death is seen by both morphological changes of apoptosis and colour change, and appears to be accompanied by death of the effector cell also. |
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Source | Movie S1 from Bhat P, Leggatt G, Matthaei K, Frazer I (2014). "The Kinematics of Cytotoxic Lymphocytes Influence Their Ability to Kill Target Cells". PLOS ONE. DOI:10.1371/journal.pone.0095248. PMID 24801876. PMC: 4011687. | ||
Author | Bhat P, Leggatt G, Matthaei K, Frazer I | ||
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This file is licensed under the Creative Commons Attribution 4.0 International license.
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Date/Time | Thumbnail | Dimensions | User | Comment | |
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current | 10:30, 12 May 2014 | 25 s, 550 × 550 (1.77 MB) | Open Access Media Importer Bot (talk | contribs) | Automatically uploaded media file from Open Access source. Please report problems or suggestions here. |
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Author | Bhat P, Leggatt G, Matthaei K, Frazer I |
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Usage terms | http://creativecommons.org/licenses/by/4.0/ |
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Software used | Xiph.Org libtheora 1.1 20090822 (Thusnelda) |
Date and time of digitizing | 2014 |
Categories:
- Cell mechanics
- Videos of cell biology
- Cell processes
- Cell death
- Videos of cell types
- Animal cells
- Videos of leukocytes
- Videos of T cells
- Cell motility
- Molecular cell biology
- Immune response
- Acquired immune system
- Immunologic techniques
- Media from PLOS ONE
- Videos of immune system uploaded with Open Access Media Importer