File:Testicular, but not ovarian lymphangiogenesis is initiated during late gestation in mice, as visualized with Prox1-EGFP transgenic gonad-mesonephros complexes.tif
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[edit]DescriptionTesticular, but not ovarian lymphangiogenesis is initiated during late gestation in mice, as visualized with Prox1-EGFP transgenic gonad-mesonephros complexes.tif |
Figure S1. Testicular, but not ovarian lymphangiogenesis is initiated during late gestation in mice, as visualized with Prox1-EGFP transgenic gonad-mesonephros complexes. A) Until 16.5 dpc, no EGFP-positive lymphatic vessels are observed in the developing testis, but are observed in the adjacent mesonephros from around 15.5 dpc. At 17.5 dpc a more extensive lymphatic network is visible along the spermatic cord and in the mesonephros, ultimately spanning out over the testis cap. From 18.5 dpc, Prox1-EGFP signal also appears from inside the testis proper, making visualization of superficial vessels difficult. T = testis; M = mesonephros. B) Comparable to XY development, the mesonephros of XX fetuses are observed to contain EGFP-positive vessels during fetal life, also prominent in the Müllerian duct between 15.5–16.5 dpc. No EGFP-positive lymphatic vessels are observed in the ovary proper during fetal life, but a rich vascular network is seen developing along the ovarian ligaments from 17.5 dpc. O = ovary; M = mesonephros; MD = Müllerian duct. C) At 19.5 dpc, no EGFP-positive vessels are observed inside the ovary, as visualized by section IF co-stained with the granulosa cell marker FOXL2. A prominent lymphatic vessel is detected in the extraovarian rete (arrow), and oocytes in the ovarian cortex are also expressing EGFP (aterisks). O = ovary; EoR = extraovarian rete; scale bar = 50 µm. https://doi.org/10.1371/journal.pone.0052620.s001 |
Date | |
Source | https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0052620 Svingen T, François M, Wilhelm D, Koopman P (2012) Three-Dimensional Imaging of Prox1-EGFP Transgenic Mouse Gonads Reveals Divergent Modes of Lymphangiogenesis in the Testis and Ovary. PLoS ONE 7(12): e52620. https://doi.org/10.1371/journal.pone.0052620 |
Author | Lim J, Maher GJ, Turner GDH, Dudka-Ruszkowska W, Taylor S, Meyts ER-D, et al. |
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[edit]© 2012 Svingen et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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current | 20:42, 2 August 2024 | ![]() | 2,043 × 2,582 (4.35 MB) | Rasbak (talk | contribs) | {{Information |description=Figure S1. Testicular, but not ovarian lymphangiogenesis is initiated during late gestation in mice, as visualized with Prox1-EGFP transgenic gonad-mesonephros complexes. A) Until 16.5 dpc, no EGFP-positive lymphatic vessels are observed in the developing testis, but are observed in the adjacent mesonephros from around 15.5 dpc. At 17.5 dpc a more extensive lymphatic network is visible along the spermatic cord and in the mesonephros, ultimately spanning out over th... |
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