File:Structural-Basis-of-Gate-DNA-Breakage-and-Resealing-by-Type-II-Topoisomerases-pone.0011338.s005.ogv

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Original file(Ogg Theora video file, length 31 s, 800 × 750 pixels, 1.97 Mbps, file size: 7.26 MB)

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English: Animated model of the DNA transport mechanism employed by a type II DNA topoisomerases. The animation is created using a model of the full-length topo IV which, in turn, is based on the crystal structure of the drug-free cleavage complex of topo IV from S. pneumoniae with cleaved DNA (reported in this paper, 3KSA, covering N-terminal domain of ParC, C-terminal domain of ParE and bound/cleaved G-segment) as well as the crystal structures of the C-terminal domain of GyrA from B. burgdorferi (1SUU)1 (for C terminal domain of ParC) and N-terminal domain of GyrB from E. coli (for N-terminal domain of ParE)2. Unbound G-segment and the transported T-segment were generated using WinCoot3. N-terminal domain of ParC is shown in blue, C-terminal domain of ParC in cyan, N-terminal domain of ParE in purple, C-terminal domain of ParE in yellow, G-segment in green and T-segment in red.
Date
Source Movie S1 from Laponogov I, Pan X, Veselkov D, McAuley K, Fisher L, Sanderson M (2010). "Structural Basis of Gate-DNA Breakage and Resealing by Type II Topoisomerases". PLOS ONE. DOI:10.1371/journal.pone.0011338. PMID 20596531. PMC: 2893164.
Author Laponogov I, Pan X, Veselkov D, McAuley K, Fisher L, Sanderson M
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This file was published in a Public Library of Science journal. Their website states that the content of all PLOS journals is published under the Creative Commons Attribution 4.0 license (or its previous version depending on the publication date), unless indicated otherwise.
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Date/TimeThumbnailDimensionsUserComment
current03:58, 17 November 201231 s, 800 × 750 (7.26 MB)Open Access Media Importer Bot (talk | contribs)Automatically uploaded media file from Open Access source. Please report problems or suggestions here.

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VP9 720P 1.32 Mbps Completed 19:51, 20 October 2018 1 min 0 s
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Streaming 144p (MJPEG) 868 kbps Completed 14:16, 19 November 2023 2.0 s

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