File:Structural-Basis-of-Gate-DNA-Breakage-and-Resealing-by-Type-II-Topoisomerases-pone.0011338.s005.ogv
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[edit]DescriptionStructural-Basis-of-Gate-DNA-Breakage-and-Resealing-by-Type-II-Topoisomerases-pone.0011338.s005.ogv |
English: Animated model of the DNA transport mechanism employed by a type II DNA topoisomerases. The animation is created using a model of the full-length topo IV which, in turn, is based on the crystal structure of the drug-free cleavage complex of topo IV from S. pneumoniae with cleaved DNA (reported in this paper, 3KSA, covering N-terminal domain of ParC, C-terminal domain of ParE and bound/cleaved G-segment) as well as the crystal structures of the C-terminal domain of GyrA from B. burgdorferi (1SUU)1 (for C terminal domain of ParC) and N-terminal domain of GyrB from E. coli (for N-terminal domain of ParE)2. Unbound G-segment and the transported T-segment were generated using WinCoot3. N-terminal domain of ParC is shown in blue, C-terminal domain of ParC in cyan, N-terminal domain of ParE in purple, C-terminal domain of ParE in yellow, G-segment in green and T-segment in red. |
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Source | Movie S1 from Laponogov I, Pan X, Veselkov D, McAuley K, Fisher L, Sanderson M (2010). "Structural Basis of Gate-DNA Breakage and Resealing by Type II Topoisomerases". PLOS ONE. DOI:10.1371/journal.pone.0011338. PMID 20596531. PMC: 2893164. | ||
Author | Laponogov I, Pan X, Veselkov D, McAuley K, Fisher L, Sanderson M | ||
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current | 03:58, 17 November 2012 | 31 s, 800 × 750 (7.26 MB) | Open Access Media Importer Bot (talk | contribs) | Automatically uploaded media file from Open Access source. Please report problems or suggestions here. |
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Author | Laponogov I, Pan X, Veselkov D, McAuley K, Fisher L, Sanderson M |
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Usage terms | http://creativecommons.org/licenses/by/3.0/ |
Image title | Animated model of the DNA transport mechanism employed by a type II DNA topoisomerases. The animation is created using a model of the full-length topo IV which, in turn, is based on the crystal structure of the drug-free cleavage complex of topo IV from S. pneumoniae with cleaved DNA (reported in this paper, 3KSA, covering N-terminal domain of ParC, C-terminal domain of ParE and bound/cleaved G-segment) as well as the crystal structures of the C-terminal domain of GyrA from B. burgdorferi (1SUU)1 (for C terminal domain of ParC) and N-terminal domain of GyrB from E. coli (for N-terminal domain of ParE)2. Unbound G-segment and the transported T-segment were generated using WinCoot3. N-terminal domain of ParC is shown in blue, C-terminal domain of ParC in cyan, N-terminal domain of ParE in purple, C-terminal domain of ParE in yellow, G-segment in green and T-segment in red. |
Software used | Xiph.Org libtheora 1.1 20090822 (Thusnelda) |
Date and time of digitizing | 2010 |