File:Sickle-Erythrocytes-Target-Cytotoxics-to-Hypoxic-Tumor-Microvessels-and-Potentiate-a-Tumoricidal-pone.0052543.s003.ogv

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Sickle-Erythrocytes-Target-Cytotoxics-to-Hypoxic-Tumor-Microvessels-and-Potentiate-a-Tumoricidal-pone.0052543.s003.ogv ‎(Ogg Theora video file, length 1 min 54 s, 640 × 480 pixels, 418 kbps, file size: 5.66 MB)

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English: Intravital microscopy of the skin window of mice using 8 day old 4T1 carcinoma infused with SSRBCs or NLRBCs. SSRBC-1: Five minutes after infusion of SSRBCs, the SSRBCs are adherent to vascular walls and deposited in relatively avascular core (circular, dark area at top) and periphery of the tumor microvasculature. Microcapillary obstruction is evident along with reduced velocity of SSRBCs as they transit through partially obstructed vessels. At 20 minutes, SSRBC microaggregates have formed in the vessels several of which have progressed to frank vaso-occlusion (Magnifications 10×). At 30 minutes, extensive aggregate formation and vaso-occlusion is noted along with retrograde blood flow in a patent capillary segment within surrounding occluded microvessels (Magnifications 20×). NLRBCs depicted 30 minutes after infusion into mice with 8 day old 4T1 carcinoma exhibit minimal adherence to tumor microvessels with no evidence of vaso-occlusion (Magnifications 10×).
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Source Movie S1 from Terman D, Viglianti B, Zennadi R, Fels D, Boruta R, Yuan H, Dreher M, Grant G, Rabbani Z, Moon E, Lan L, Eble J, Cao Y, Sorg B, Ashcraft K, Palmer G, Telen M, Dewhirst M (2013). "Sickle Erythrocytes Target Cytotoxics to Hypoxic Tumor Microvessels and Potentiate a Tumoricidal Response". PLOS ONE. DOI:10.1371/journal.pone.0052543. PMID 23326340. PMC: 3541382.
Author Terman D, Viglianti B, Zennadi R, Fels D, Boruta R, Yuan H, Dreher M, Grant G, Rabbani Z, Moon E, Lan L, Eble J, Cao Y, Sorg B, Ashcraft K, Palmer G, Telen M, Dewhirst M
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Date/TimeThumbnailDimensionsUserComment
current04:45, 19 January 20131 min 54 s, 640 × 480 (5.66 MB)Open Access Media Importer Bot (talk | contribs)Automatically uploaded media file from Open Access source. Please report problems or suggestions here.

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Format Bitrate Download Status Encode time
VP9 480P 173 kbps Completed 14:28, 19 October 2018 1 min 7 s
Streaming 480p (VP9) Not ready Unknown status
VP9 360P 82 kbps Completed 14:28, 19 October 2018 1 min 7 s
Streaming 360p (VP9) Not ready Unknown status
VP9 240P 48 kbps Completed 14:27, 19 October 2018 42 s
Streaming 240p (VP9) 49 kbps Completed 23:51, 15 December 2023 1.0 s
WebM 360P 419 kbps Completed 05:01, 19 January 2013 1 min 24 s
Streaming 144p (MJPEG) 642 kbps Completed 15:21, 17 November 2023 3.0 s

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