File:Sickle-Erythrocytes-Target-Cytotoxics-to-Hypoxic-Tumor-Microvessels-and-Potentiate-a-Tumoricidal-pone.0052543.s003.ogv
Sickle-Erythrocytes-Target-Cytotoxics-to-Hypoxic-Tumor-Microvessels-and-Potentiate-a-Tumoricidal-pone.0052543.s003.ogv (Ogg Theora video file, length 1 min 54 s, 640 × 480 pixels, 418 kbps, file size: 5.66 MB)
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[edit]DescriptionSickle-Erythrocytes-Target-Cytotoxics-to-Hypoxic-Tumor-Microvessels-and-Potentiate-a-Tumoricidal-pone.0052543.s003.ogv |
English: Intravital microscopy of the skin window of mice using 8 day old 4T1 carcinoma infused with SSRBCs or NLRBCs. SSRBC-1: Five minutes after infusion of SSRBCs, the SSRBCs are adherent to vascular walls and deposited in relatively avascular core (circular, dark area at top) and periphery of the tumor microvasculature. Microcapillary obstruction is evident along with reduced velocity of SSRBCs as they transit through partially obstructed vessels. At 20 minutes, SSRBC microaggregates have formed in the vessels several of which have progressed to frank vaso-occlusion (Magnifications 10×). At 30 minutes, extensive aggregate formation and vaso-occlusion is noted along with retrograde blood flow in a patent capillary segment within surrounding occluded microvessels (Magnifications 20×). NLRBCs depicted 30 minutes after infusion into mice with 8 day old 4T1 carcinoma exhibit minimal adherence to tumor microvessels with no evidence of vaso-occlusion (Magnifications 10×). |
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Source | Movie S1 from Terman D, Viglianti B, Zennadi R, Fels D, Boruta R, Yuan H, Dreher M, Grant G, Rabbani Z, Moon E, Lan L, Eble J, Cao Y, Sorg B, Ashcraft K, Palmer G, Telen M, Dewhirst M (2013). "Sickle Erythrocytes Target Cytotoxics to Hypoxic Tumor Microvessels and Potentiate a Tumoricidal Response". PLOS ONE. DOI:10.1371/journal.pone.0052543. PMID 23326340. PMC: 3541382. | ||
Author | Terman D, Viglianti B, Zennadi R, Fels D, Boruta R, Yuan H, Dreher M, Grant G, Rabbani Z, Moon E, Lan L, Eble J, Cao Y, Sorg B, Ashcraft K, Palmer G, Telen M, Dewhirst M | ||
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Date/Time | Thumbnail | Dimensions | User | Comment | |
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current | 04:45, 19 January 2013 | 1 min 54 s, 640 × 480 (5.66 MB) | Open Access Media Importer Bot (talk | contribs) | Automatically uploaded media file from Open Access source. Please report problems or suggestions here. |
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Author | Terman D, Viglianti B, Zennadi R, Fels D, Boruta R, Yuan H, Dreher M, Grant G, Rabbani Z, Moon E, Lan L, Eble J, Cao Y, Sorg B, Ashcraft K, Palmer G, Telen M, Dewhirst M |
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Usage terms | http://creativecommons.org/licenses/by/3.0/ |
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Software used | Xiph.Org libtheora 1.1 20090822 (Thusnelda) |
Date and time of digitizing | 2013 |