File:Sertoli Cell Precursors Switch from Expression of Male to Female Pathway Genes.png
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Figure 4. Sertoli Cell Precursors Switch from Expression of Male to Female Pathway Genes (A–F) Whole-mount in situ hybridization for genes in the male pathway downstream of Sox9, Dhh, and Amh. Dhh expression is disrupted in XY Fgf9−/− gonads (g) at 11.5 dpc (A and B). Amh expression is severely reduced in XY Fgf9−/− gonads at 12.5 dpc (E and F). (G and H) Analysis of cell death in Fgf9−/− XY gonads using an apoptotic marker, active caspase-3 (red). No increased apoptosis is observed in XY Fgf9−/− gonads (g) compared with control XY gonads, although apoptotic cells are increased around mesonephric tubules (m) of the mutant gonads (arrow in H). Semitransparent dotted line indicates boundary between mesonephros and gonad. (PECAM, green). (I–K) Whole-mount in situ hybridization for Wnt4, an ovary marker. Wnt4 is expressed in Fgf9−/− XY gonads at 12.5 dpc (K) similar to the level in XX Fgf9+/− controls (I) but not in XY controls (J). The scale bars represent 50 μm. g, gonad; m, mesonephros. |
| Date | |
| Source | https://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.0040187 Fgf9 and Wnt4 Act as Antagonistic Signals to Regulate Mammalian Sex Determination . PLoS Biol 4(6): e187. https://doi.org/10.1371/journal.pbio.0040187 |
| Author | Kim Y, Kobayashi A, Sekido R, DiNapoli L, Brennan J, Chaboissier M-C, et al. |
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© 2006 Kim et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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| Date/Time | Thumbnail | Dimensions | User | Comment | |
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| current | 14:26, 9 July 2024 | | 2,984 × 2,476 (5.45 MB) | Rasbak (talk | contribs) | {{Information |description= Figure 4. Sertoli Cell Precursors Switch from Expression of Male to Female Pathway Genes (A–F) Whole-mount in situ hybridization for genes in the male pathway downstream of Sox9, Dhh, and Amh. Dhh expression is disrupted in XY Fgf9−/− gonads (g) at 11.5 dpc (A and B). Amh expression is severely reduced in XY Fgf9−/− gonads at 12.5 dpc (E and F). (G and H) Analysis of cell death in Fgf9−/− XY gonads using an apoptotic marker, active caspase-3 (red). No increased ap... |
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