File:SARS-CoV-2 spike protein induces cognitive deficit and anxiety-like behavior in mouse via non-cell autonomous hippocampal neuronal death.pdf
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SARS-CoV-2 spike protein induces cognitive deficit and anxiety-like behavior in mouse via non-cell autonomous hippocampal neuronal death
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[edit]DescriptionSARS-CoV-2 spike protein induces cognitive deficit and anxiety-like behavior in mouse via non-cell autonomous hippocampal neuronal death.pdf |
English: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is accompanied by chronic neurological sequelae such as cognitive decline and mood disorder, but the underlying mechanisms have not yet been elucidated. We explored the possibility that the brain-infiltrating SARS-CoV-2 spike protein contributes to the development of neurological symptoms observed in COVID-19 patients in this study. Our behavioral study showed that administration of SARS-CoV-2 spike protein S1 subunit (S1 protein) to mouse hippocampus induced cognitive deficit and anxiety-like behavior in vivo. These neurological symptoms were accompanied by neuronal cell death in the dorsal and ventral hippocampus as well as glial cell activation. Interestingly, the S1 protein did not directly induce hippocampal cell death in vitro. Rather, it exerted neurotoxicity via glial cell activation, partially through interleukin-1β induction. In conclusion, our data suggest a novel pathogenic mechanism for the COVID-19-associated neurological symptoms that involves glia activation and non-cell autonomous hippocampal neuronal death by the brain-infiltrating S1 protein. |
Date | |
Source | https://www.nature.com/articles/s41598-022-09410-7 |
Author | Junyoung Oh, Woo-Hyun Cho, Ellane Barcelon, Kwang Hwan Kim, Jinpyo Hong & Sung Joong Lee |
doi:10.1038/s41598-022-09410-7
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current | 00:22, 4 April 2022 | ![]() | 1,239 × 1,629, 10 pages (11.7 MB) | Koavf (talk | contribs) | Uploaded a work by Junyoung Oh, Woo-Hyun Cho, Ellane Barcelon, Kwang Hwan Kim, Jinpyo Hong & Sung Joong Lee from https://www.nature.com/articles/s41598-022-09410-7 with UploadWizard |
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Publisher | Nature Publishing Group UK |
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Date and time of digitizing | 02:13, 1 April 2022 |
Software used | Springer |
File change date and time | 21:53, 31 March 2022 |
Date metadata was last modified | 21:53, 31 March 2022 |
Identifier | https://doi.org/10.1038/s41598-022-09410-7 |
Conversion program | Adobe PDF Library 15.0; modified using iText® 5.3.5 ©2000-2012 1T3XT BVBA (SPRINGER SBM; licensed version) |
Encrypted | no |
Page size | 595.276 x 782.362 pts |
Version of PDF format | 1.6 |