File:Phosphorylation-by-PINK1-Releases-the-UBL-Domain-and-Initializes-the-Conformational-Opening-of-the-pcbi.1003935.s011.ogv

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Original file ‎(Ogg Theora video file, length 39 s, 1,280 × 720 pixels, 3.6 Mbps, file size: 16.81 MB)

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Description
English: The improved human Parkin model. A model for human full-length Parkin is shown with legend key for domain residues in lower left corner. Initial closed, auto-inhibited state for Parkin is shown. As animation progresses the surface of the protein is shown semi-transparent to account for the solvent-accessible surface area of Parkin. Surfaces are colored to match domains as indicated in Figure 1. Parkin then rotates 360° in the X-axis followed by Y-axis. Following the surface rendered pose, the partial open state is shown for a pSer65 activated Parkin model. The UBL-linker regions are adjusted away from IBR and REP region, prior to large movement across body of protein.
Date
Source Movie S1 from Caulfield T, Fiesel F, Moussaud-Lamodiere E, Dourado D, Flores S, Springer W (2014). "Phosphorylation by PINK1 Releases the UBL Domain and Initializes the Conformational Opening of the E3 Ubiquitin Ligase Parkin". PLOS Computational Biology. DOI:10.1371/journal.pcbi.1003935. PMID 25375667. PMC: 4222639.
Author Caulfield T, Fiesel F, Moussaud-Lamodiere E, Dourado D, Flores S, Springer W
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This file is licensed under the Creative Commons Attribution 4.0 International license.
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This file was transferred to Wikimedia Commons from PubMed Central by way of the Open Access Media Importer.
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Date/TimeThumbnailDimensionsUserComment
current22:26, 16 November 201439 s, 1,280 × 720 (16.81 MB)Open Access Media Importer Bot (talk | contribs)Automatically uploaded media file from Open Access source. Please report problems or suggestions here.

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Format Bitrate Download Status Encode time
VP9 720P 1.43 Mbps Completed 16:59, 13 October 2018 1 min 2 s
Streaming 720p (VP9) Not ready Unknown status
VP9 480P 828 kbps Completed 16:59, 13 October 2018 44 s
Streaming 480p (VP9) Not ready Unknown status
VP9 360P 417 kbps Completed 16:59, 13 October 2018 33 s
Streaming 360p (VP9) Not ready Unknown status
VP9 240P 209 kbps Completed 16:59, 13 October 2018 33 s
Streaming 240p (VP9) 209 kbps Completed 21:13, 5 December 2023 1.0 s
WebM 360P 333 kbps Completed 22:26, 16 November 2014 33 s
Streaming 144p (MJPEG) 814 kbps Completed 21:18, 18 November 2023 1.0 s

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