File:Pathways-of-allosteric-regulation-in-Hsp70-chaperones-ncomms9308-s3.ogv

English: Supplementary Movie 2 Supplementary Movie 2 (related to Fig. 2A): Movements of Val440 and Leu484 during transition from the open to the substrate bound conformation. The movie shows a morph of the SBDβ in cartoon representation starting from the structure of the ATP bound open conformation of E. coli DnaK (PDB ID 4B9Q) morphing into the structure of the isolated SBD of E. coli DnaK in complex with a peptide (PDB ID 1DKX and back (top view; L7,8 and strain 8 left away for clarity). In space filling representation are shown residues Leu484 (left) and Val440 (middle), and the residues Phe426 and Ile438, which line the substrate binding pocket (right). For residues Val440, Phe426, and Ile438 only Cα, and side chain atoms are shown. Morph was created on The Yale Morph Server (http://molmovdb.org/morph/) and visualized in PyMOL (The PyMOL Molecular Graphics System, Version 1.7.4 Schrödinger, LLC).