File:Parkinson's-Disease–Associated-Kinase-PINK1-Regulates-Miro-Protein-Level-and-Axonal-Transport-of-pgen.1002537.s007.ogv
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[edit]DescriptionParkinson's-Disease–Associated-Kinase-PINK1-Regulates-Miro-Protein-Level-and-Axonal-Transport-of-pgen.1002537.s007.ogv |
English: Fis1-OE promotes mitochondrial flux in the axons of Drosophila larval segment neurons. Representative time-lapse video of mitochondrial movement in a segment neuron of Fis1-OE Drosophila larva is shown. Mitochondrial movement was visualized by the mitoGFP fluorescence. Overexpression of the mitochondrial fission protein Fis1 (FIs1-OE) decreases mitochondrial length but increases mitochondrial flux in both anterograde and retrograde directions. Mitochondrial movement to the left represents anterograde axonal transport. The video was acquired at a speed of 2 sec/frame and played at 4 frames/sec (1 s movie time = 8 s real time). |
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Source | Video S6 from Liu S, Sawada T, Lee S, Yu W, Silverio G, Alapatt P, Millan I, Shen A, Saxton W, Kanao T, Takahashi R, Hattori N, Imai Y, Lu B (2012). "Parkinson's Disease–Associated Kinase PINK1 Regulates Miro Protein Level and Axonal Transport of Mitochondria". PLOS Genetics. DOI:10.1371/journal.pgen.1002537. PMID 22396657. PMC: 3291531. | ||
Author | Liu S, Sawada T, Lee S, Yu W, Silverio G, Alapatt P, Millan I, Shen A, Saxton W, Kanao T, Takahashi R, Hattori N, Imai Y, Lu B | ||
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Date/Time | Thumbnail | Dimensions | User | Comment | |
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current | 04:38, 16 November 2012 | 38 s, 1,023 × 155 (2.19 MB) | Open Access Media Importer Bot (talk | contribs) | Automatically uploaded media file from Open Access source. Please report problems or suggestions here. |
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Author | Liu S, Sawada T, Lee S, Yu W, Silverio G, Alapatt P, Millan I, Shen A, Saxton W, Kanao T, Takahashi R, Hattori N, Imai Y, Lu B |
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Usage terms | http://creativecommons.org/licenses/by/3.0/ |
Image title | Fis1-OE promotes mitochondrial flux in the axons of Drosophila larval segment neurons. Representative time-lapse video of mitochondrial movement in a segment neuron of Fis1-OE Drosophila larva is shown. Mitochondrial movement was visualized by the mitoGFP fluorescence. Overexpression of the mitochondrial fission protein Fis1 (FIs1-OE) decreases mitochondrial length but increases mitochondrial flux in both anterograde and retrograde directions. Mitochondrial movement to the left represents anterograde axonal transport. The video was acquired at a speed of 2 sec/frame and played at 4 frames/sec (1 s movie time? |
Software used | Xiph.Org libtheora 1.1 20090822 (Thusnelda) |
Date and time of digitizing | 2012-03 |
Categories:
- Videos of neuronal mitochondria
- Axonal transport
- Carbonyl cyanide m-chlorophenyl hydrazone
- Animal models of disease
- Dopaminergic neurons
- Videos of Drosophila
- Drosophila proteins
- Gene expression regulation
- Motor neurons
- Mutant proteins
- Videos of Parkinson's disease
- Protein-serine-threonine kinases
- Proton ionophores
- Ubiquitin-protein ligases
- Videos of Rho family of GTPases