File:One-Small-Step-for-a-Yeast---Microevolution-within-Macrophages-Renders-Candida-glabrata-ppat.1004478.s013.ogv
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One-Small-Step-for-a-Yeast---Microevolution-within-Macrophages-Renders-Candida-glabrata-ppat.1004478.s013.ogv (Ogg Theora video file, length 59 s, 640 × 480 pixels, 2.19 Mbps, file size: 15.32 MB)
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[edit]DescriptionOne-Small-Step-for-a-Yeast---Microevolution-within-Macrophages-Renders-Candida-glabrata-ppat.1004478.s013.ogv |
English: The Evo strain escapes RAW 246.7 macrophages by pseudohyphal outgrowth. Macrophages were infected with sonicated cells of the Evo strain at a MOI of 2∶1. After 60 min of phagocytosis, non-attached yeasts were washed away and time-lapse microscopy was started. Phagocytosed fungal cells continued to grow in a pseudohyphae-like morphology within the macrophages (red arrow), which finally led to host cell rupture and the attraction of numerous macrophages (white arrows). Starting at approximately 48 h, macrophages burst (examples shown by black arrows 1–4) and C. glabrata cells escaped to overgrow the macrophages. |
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Source | Video S1 from Brunke S, Seider K, Fischer D, Jacobsen I, Kasper L, Jablonowski N, Wartenberg A, Bader O, Enache-Angoulvant A, Schaller M, d'Enfert C, Hube B (2014). "One Small Step for a Yeast - Microevolution within Macrophages Renders Candida glabrata Hypervirulent Due to a Single Point Mutation". PLOS Pathogens. DOI:10.1371/journal.ppat.1004478. PMID 25356907. PMC: 4214790. | ||
Author | Brunke S, Seider K, Fischer D, Jacobsen I, Kasper L, Jablonowski N, Wartenberg A, Bader O, Enache-Angoulvant A, Schaller M, d'Enfert C, Hube B | ||
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![]() ![]() This file is licensed under the Creative Commons Attribution 4.0 International license.
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Date/Time | Thumbnail | Dimensions | User | Comment | |
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current | 02:44, 14 November 2014 | 59 s, 640 × 480 (15.32 MB) | Open Access Media Importer Bot (talk | contribs) | Automatically uploaded media file from Open Access source. Please report problems or suggestions here. |
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Author | Brunke S, Seider K, Fischer D, Jacobsen I, Kasper L, Jablonowski N, Wartenberg A, Bader O, Enache-Angoulvant A, Schaller M, d'Enfert C, Hube B |
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Usage terms | http://creativecommons.org/licenses/by/4.0/ |
Image title | The Evo strain escapes RAW 246.7 macrophages by pseudohyphal outgrowth. Macrophages were infected with sonicated cells of the Evo strain at a MOI of 2∶1. After 60 min of phagocytosis, non-attached yeasts were washed away and time-lapse microscopy was started. Phagocytosed fungal cells continued to grow in a pseudohyphae-like morphology within the macrophages (red arrow), which finally led to host cell rupture and the attraction of numerous macrophages (white arrows). Starting at approximately 48 h, macrophages burst (examples shown by black arrows 1–4) and C. glabrata cells escaped to overgrow the macrophages. |
Software used | Xiph.Org libtheora 1.1 20090822 (Thusnelda) |
Date and time of digitizing | 2014-10 |