File:Myocardial-contractility-in-the-stress-echo-lab-from-pathophysiological-toy-to-clinical-tool-1476-7120-11-41-S5.ogv

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Myocardial-contractility-in-the-stress-echo-lab-from-pathophysiological-toy-to-clinical-tool-1476-7120-11-41-S5.ogv (Ogg multiplexed audio/video file, Theora/Vorbis, length 2 min 26 s, 648 × 486 pixels, 4.48 Mbps overall, file size: 78.05 MB)

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English: Dilated Cardiomyopathy: Calcium re-uptake. Clearing of intracellular Calcium is carried out by the Sarcoplasmic Reticulum Calcium Pump (known as SERCA), a very efficient protein capable of concentrating Calcium at a rate of two ions for one ATP. One of the molecular defects of the dilated heart is the reduced efficiency of this pump: this is physiologically counterbalanced by a higher expression (and more intense activation) of the Na+/Ca2+ exchanger of the plasma membrane. The problem is especially felt under stress: in this condition, with faster cycles, even more Calcium is released, aggravating the burden of re-uptake on the defective SERCA, not well-complemented by the activity of the plasma membrane exchanger. Since this pump is also inefficient, the final result is that blood circulation is not sustained to the required level. (The full quality video can be accessed at this link: https://vimeo.com/79085978).
Date
Source Bombardini T, Zoppe M, Ciampi Q, Cortigiani L, Agricola E, Salvadori S, Loni T, Pratali L, Picano E (2013). "Myocardial contractility in the stress echo lab: from pathophysiological toy to clinical tool". Cardiovascular Ultrasound. DOI:10.1186/1476-7120-11-41. PMID 24246005. PMC: 3875530.
Author Bombardini T, Zoppe M, Ciampi Q, Cortigiani L, Agricola E, Salvadori S, Loni T, Pratali L, Picano E
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current03:51, 1 January 20142 min 26 s, 648 × 486 (78.05 MB)Open Access Media Importer Bot (talk | contribs)Automatically uploaded media file from Open Access source. Please report problems or suggestions here.

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Format Bitrate Download Status Encode time
VP9 480P 1.25 Mbps Completed 04:27, 4 September 2018 4 min 4 s
VP9 360P 693 kbps Completed 04:26, 4 September 2018 2 min 57 s
VP9 240P 415 kbps Completed 04:27, 4 September 2018 4 min 18 s
WebM 360P 504 kbps Completed 03:55, 1 January 2014 3 min 19 s
QuickTime 144p (MJPEG) 949 kbps Completed 06:26, 12 October 2024 6.0 s

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