File:Morphological changes and somatic cell differentiation along the cortical-medullary axis from the bipotential gonadal primordium at E10.5t o the differentiated ovary around P5.png

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Figure 2. Schematic representation showing morphological changes and somatic cell differentiation along the cortical-medullary axis during fetal and postnatal stages, from the bipotential gonadal primordium at E10.5 to the differentiated ovary around P5.
(A) At E10.5, the CE cells proliferate and ingress into the gonadal parenchyma, controlled by the NUMB distribution (magenta) and Notch signaling, to form primary sex cords without sexual dimorphism.
(B) At E12.5, supporting cell precursors in the medullary region (green cells) express an early ovarian factor, FOXL2 (red). In contrast to testis differentiation, the proliferation and ingression of the CE in XX gonads continues after E12.5, leading to the formation of secondary sex cords in the cortical region (orange cells). Supporting cell precursors in secondary sex cords, including CE cells, express the transmembrane receptor LGR5 (blue). LGR5 and FOXL2 expression is mutually exclusive, and it exhibits a gradient from the cortex (CE side) to the medulla (mesonephric side). Other somatic cells (i.e., interstitial precursor cells) also exclusively express NR2F2 (deep green). Germ cells (GCs) initiate meiosis at E12.5 (deep purple, condensed chromosomes).

(C) At postnatal stages, FOXL2-positive granulosa cells in primary sex cords in the medullary region contribute to the formation of the first wave of follicles. In the cortical region, granulosa cells that originate from LGR5-positive cells (orange cells) form the secondary sex cords and primordial follicle pools. After sexual maturity, these follicles develop according to the estrous cycle.
Date
Source https://www.researchgate.net/publication/365064403_Gonadal_Sex_Differentiation_and_Ovarian_Organogenesis_along_the_Cortical-Medullary_Axis_in_Mammals Gonadal Sex Differentiation and Ovarian Organogenesis along the Cortical–Medullary Axis in Mammals. Int. J. Mol. Sci. 2022,23, 13373. https://doi.org/10.3390/ijms232113373
Author Imaimatsu, K.; Uchida, A.; Hiramatsu, R.; Kanai, Y.
This file, which was originally posted to an external website, has not yet been reviewed by an administrator or reviewer to confirm that the above license is valid. See Category:License review needed for further instructions.

Copyright: © 2022 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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This file is licensed under the Creative Commons Attribution 4.0 International license.
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Description Figure 2. Sertoli-Leydig cell tumor with cords and Leydig cell nests (A, HE stain) with a profile GATA-4 positive (B) and FOG-2 positive: thick arrow, Leydig cells FOG-2 negative; thin arrow, Sertoli cells FOG-2 positive (C).
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Source https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0045914 GATA-4 and FOG-2 Expression in Pediatric Ovarian Sex Cord-Stromal Tumors Replicates Embryonal Gonadal Phenotype: Results from the TREP Project. PLoS ONE 7(9): e45914. https://doi.org/10.1371/journal.pone.0045914
Author Virgone C, Cecchetto G, Ferrari A, Bisogno G, Donofrio V, Boldrini R, et al.
This file, which was originally posted to an external website, has not yet been reviewed by an administrator or reviewer to confirm that the above license is valid. See Category:License review needed for further instructions.

© Virgone et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Licensing

[edit]
w:en:Creative Commons
attribution
This file is licensed under the Creative Commons Attribution 4.0 International license.
You are free:
  • to share – to copy, distribute and transmit the work
  • to remix – to adapt the work
Under the following conditions:
  • attribution – You must give appropriate credit, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use.

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current00:36, 5 July 2024Thumbnail for version as of 00:36, 5 July 20243,526 × 3,465 (2.16 MB)Rasbak (talk | contribs)
18:55, 4 July 2024Thumbnail for version as of 18:55, 4 July 2024850 × 839 (458 KB)Rasbak (talk | contribs){{Information |description= Figure 2. Schematic representation showing morphological changes and somatic cell differentiation along the cortical-medullary axis during fetal and postnatal stages, from the bipotential gonadal primordium at E10.5 to the differentiated ovary around P5. (A) At E10.5, the CE cells proliferate and ingress into the gonadal parenchyma, controlled by the NUMB distribution (magenta) and Notch signaling, to form primary sex cords without sexual dimorphism. (B) At E12.5,...

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