File:Molecular-Dynamics-of-Fuzzy-Transcriptional-Activator-Coactivator-Interactions-pcbi.1004935.s003.ogv

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Original file (Ogg Theora video file, length 33 s, 896 × 992 pixels, 10.79 Mbps, file size: 42.89 MB)

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Description
English: Contacts between GCN4 M107 with leucines in GAL11-ABD1. The GAL11-ABD1 structure is shown as a cartoon representation in silver. The GCN4 cAD is drawn as a purple ribbon. The GCN4 hydrophobic residues W120, F124 and M107 are displayed as liquorice models in cyan, neon green and magenta, respectively. Two leucine residues in GAL11-ABD1, L169 and L227 are shown as light blue liquorice models. At the start of the movie (0–18 seconds), M107 takes up a number of different positions on the coactivator surface. M107 then establishes contact with L227 (seconds 19 to 23) and also contacting L169 (seconds 22 to 33) at irregular intervals. The trajectory is from GAL11-ABD1/GCN4-cAD_aMD_no2 and represents one microsecond of accelerated aMD.
Date
Source S2 Movie from Scholes N, Weinzierl R (2016). "Molecular Dynamics of "Fuzzy" Transcriptional Activator-Coactivator Interactions". PLOS Computational Biology. DOI:10.1371/journal.pcbi.1004935. PMID 27175900. PMC: 4866707.
Author Scholes N, Weinzierl R
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This file was transferred to Wikimedia Commons from PubMed Central by way of the Open Access Media Importer.
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Date/TimeThumbnailDimensionsUserComment
current07:08, 18 October 201633 s, 896 × 992 (42.89 MB)Open Access Media Importer Bot (talk | contribs)Automatically uploaded media file from Open Access source. Please report problems or suggestions here.

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