File:Melatonin for the prevention and treatment of cancer.pdf
Jump to navigation
Jump to search
Size of this JPG preview of this PDF file: 463 × 599 pixels. Other resolutions: 185 × 240 pixels | 371 × 480 pixels | 593 × 768 pixels | 1,275 × 1,650 pixels.
Original file (1,275 × 1,650 pixels, file size: 1.27 MB, MIME type: application/pdf, 26 pages)
Captions
Captions
Melatonin for the prevention and treatment of cancer
Summary
[edit]| Description |
English: The epidemiological studies have indicated a possible oncostatic property of melatonin on different types of tumors. Besides, experimental studies have documented that melatonin could exert growth inhibition on some human tumor cells in vitro and in animal models. The underlying mechanisms include antioxidant activity, modulation of melatonin receptors MT1 and MT2, stimulation of apoptosis, regulation of pro-survival signaling and tumor metabolism, inhibition on angiogenesis, metastasis, and induction of epigenetic alteration. Melatonin could also be utilized as adjuvant of cancer therapies, through reinforcing the therapeutic effects and reducing the side effects of chemotherapies or radiation. Melatonin could be an excellent candidate for the prevention and treatment of several cancers, such as breast cancer, prostate cancer, gastric cancer and colorectal cancer. This review summarized the anticancer efficacy of melatonin, based on the results of epidemiological, experimental and clinical studies, and special attention was paid to the mechanisms of action. |
| Date | |
| Source | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5503661/pdf/oncotarget-08-39896.pdf |
| Author | Ya Li, Sha Li, Yue Zhou, Xiao Meng, Jiao-Jiao Zhang, Dong-Ping Xu and HuaBin Li |
Licensing
[edit]
This file is licensed under the Creative Commons Attribution 4.0 International license.
- You are free:
- to share – to copy, distribute and transmit the work
- to remix – to adapt the work
- Under the following conditions:
- attribution – You must give appropriate credit, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use.
File history
Click on a date/time to view the file as it appeared at that time.
| Date/Time | Thumbnail | Dimensions | User | Comment | |
|---|---|---|---|---|---|
| current | 09:38, 31 January 2022 |  | 1,275 × 1,650, 26 pages (1.27 MB) | Koavf (talk | contribs) | Uploaded a work by Ya Li, Sha Li, Yue Zhou, Xiao Meng, Jiao-Jiao Zhang, Dong-Ping Xu and HuaBin Li from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5503661/pdf/oncotarget-08-39896.pdf with UploadWizard |
You cannot overwrite this file.
File usage on Commons
The following 2 pages use this file: