File:Mathematical-Modeling-Predicts-that-Increased-HSV-2-Shedding-in-HIV-1-Infected-Persons-Is-Due-to-pone.0155124.s010.ogv

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English: HSV-2 shedding simulation with parameters derived from HIV negative study participants. The upper left panel represents total cell-free HSV DNA copies / mL present over time. The upper right panel represents spatial spread of cell-free virus during the episode. The lower left panel represents CD8+ T-cell density within each region. The lower right panel indicates reproductive number within each region. Quantities are displayed according to a heat map adjacent to each spatial map. The reproductive number (R) represents the growth potential of virus in a given region and is inversely correlated with CD+ T-cell density: values less than 1 (log 10 R = 0) are grey or black and indicate no potential for extended viral spread, while values exceeding 1 indicate potential for prolonged viral growth.
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Source S1 Movie from Schiffer J, Swan D, Magaret A, Schacker T, Wald A, Corey L (2016). "Mathematical Modeling Predicts that Increased HSV-2 Shedding in HIV-1 Infected Persons Is Due to Poor Immunologic Control in Ganglia and Genital Mucosa". PLOS ONE. DOI:10.1371/journal.pone.0155124. PMID 27285483. PMC: 4902308.
Author Schiffer J, Swan D, Magaret A, Schacker T, Wald A, Corey L
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This file is licensed under the Creative Commons Attribution 4.0 International license.
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current04:18, 13 October 20161 min 19 s, 1,920 × 1,080 (4.25 MB)Open Access Media Importer Bot (talk | contribs)Automatically uploaded media file from Open Access source. Please report problems or suggestions here.

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VP9 1080P 237 kbps Completed 23:58, 2 September 2018 33 s
VP9 720P 93 kbps Completed 23:57, 2 September 2018 26 s
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