File:In-vivo-characterization-of-microglial-engulfment-of-dying-neurons-in-the-zebrafish-spinal-cord-Video4.ogv
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[edit]DescriptionIn-vivo-characterization-of-microglial-engulfment-of-dying-neurons-in-the-zebrafish-spinal-cord-Video4.ogv |
English: UV ablation of a GFP-expressing spinal cord motor neuron (green) results in immediate microglia (red) response. One of the two surrounding microglia quickly relocates toward the ablated neuron and starts to phagocytose the remnants of the dying neuron. This activated microglia displays a profound change in morphology (from a ramified appearance to a spherical shape). After approximately 2.5 h the phagocytosing glial cell reverts back to a ramified morphology, indicating termination of the phagocytosis process. Interestingly only one microglia actively phagocytoses the dying neuron while other microglia pass by and ignore the site of neuronal ablation, even after the phagocytosing microglia has departed (6 min/frame, overall duration ~10 h). |
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Source | Supplementary Video 4 from Morsch M, Radford R, Lee A, Don E, Badrock A, Hall T, Cole N, Chung R (2015). "In vivo characterization of microglial engulfment of dying neurons in the zebrafish spinal cord". Frontiers in Cellular Neuroscience. DOI:10.3389/fncel.2015.00321. PMC: 4553390. | ||
Author | Morsch M, Radford R, Lee A, Don E, Badrock A, Hall T, Cole N, Chung R | ||
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This file is licensed under the Creative Commons Attribution 4.0 International license.
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Date/Time | Thumbnail | Dimensions | User | Comment | |
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current | 21:51, 15 September 2015 | 17 s, 1,024 × 1,024 (3.73 MB) | Open Access Media Importer Bot (talk | contribs) | Automatically uploaded media file from Open Access source. Please report problems or suggestions here. |
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Author | Morsch M, Radford R, Lee A, Don E, Badrock A, Hall T, Cole N, Chung R |
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Usage terms | http://creativecommons.org/licenses/by/4.0/ |
Image title | UV ablation of a GFP-expressing spinal cord motor neuron (green) results in immediate microglia (red) response. One of the two surrounding microglia quickly relocates toward the ablated neuron and starts to phagocytose the remnants of the dying neuron. This activated microglia displays a profound change in morphology (from a ramified appearance to a spherical shape). After approximately 2.5 h the phagocytosing glial cell reverts back to a ramified morphology, indicating termination of the phagocytosis process. Interestingly only one microglia actively phagocytoses the dying neuron while other microglia pass by and ignore the site of neuronal ablation, even after the phagocytosing microglia has departed (6 min/frame, overall duration ~10 h). |
Software used | Xiph.Org libtheora 1.1 20090822 (Thusnelda) |
Date and time of digitizing | 2015-08-31 |