File:In-Vivo-Imaging-Reveals-Distinct-Inflammatory-Activity-of-CNS-Microglia-versus-PNS-Macrophages-in-a-pone.0017910.s004.ogv
In-Vivo-Imaging-Reveals-Distinct-Inflammatory-Activity-of-CNS-Microglia-versus-PNS-Macrophages-in-a-pone.0017910.s004.ogv (Ogg Theora video file, length 9.1 s, 504 × 458 pixels, 1.53 Mbps, file size: 1.66 MB)
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[edit]DescriptionIn-Vivo-Imaging-Reveals-Distinct-Inflammatory-Activity-of-CNS-Microglia-versus-PNS-Macrophages-in-a-pone.0017910.s004.ogv |
English: Early phagocytosis after a single axon transection in the lateral column of a preclinical SOD1G93A mouse. This video sequence (90-minute) lasts from 15 minutes before to 75 minutes after an axonal transection in a 75-day-old mutant mouse. It shows, similar to the Video S3, an increased response of microglia towards the injured site (note the autofluorescence in the image center; arrow). The response comprised an early phagocytic activity of microglia at both sides of the injury. Note the engulfment and the subsequent phagocytosis of an EYFP-containing bulb-like swelling of the transected degenerating axon about 30 µm to the right to the injured site (arrow). The frame rate of the video is 85 seconds per MIP. Scale bar, 20 µm. |
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Source | Video S4 from Dibaj P, Steffens H, Zschuntzsch J, Nadrigny F, Schomburg E, Kirchhoff F, Neusch C (2011). "In Vivo Imaging Reveals Distinct Inflammatory Activity of CNS Microglia versus PNS Macrophages in a Mouse Model for ALS". PLOS ONE. DOI:10.1371/journal.pone.0017910. PMID 21437247. PMC: 3060882. | ||
Author | Dibaj P, Steffens H, Zschuntzsch J, Nadrigny F, Schomburg E, Kirchhoff F, Neusch C | ||
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Date/Time | Thumbnail | Dimensions | User | Comment | |
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current | 21:59, 28 May 2013 | 9.1 s, 504 × 458 (1.66 MB) | Open Access Media Importer Bot (talk | contribs) | Automatically uploaded media file from Open Access source. Please report problems or suggestions here. |
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Author | Dibaj P, Steffens H, Zschuntzsch J, Nadrigny F, Schomburg E, Kirchhoff F, Neusch C |
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Usage terms | http://creativecommons.org/licenses/by/3.0/ |
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Software used | Xiph.Org libtheora 1.1 20090822 (Thusnelda) |
Date and time of digitizing | 2011 |