File:Glucose-Oscillations-Can-Activate-an-Endogenous-Oscillator-in-Pancreatic-Islets-pcbi.1005143.s003.ogv
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Glucose-Oscillations-Can-Activate-an-Endogenous-Oscillator-in-Pancreatic-Islets-pcbi.1005143.s003.ogv (Ogg Theora video file, length 36 s, 585 × 180 pixels, 1.54 Mbps, file size: 6.61 MB)
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[edit]DescriptionGlucose-Oscillations-Can-Activate-an-Endogenous-Oscillator-in-Pancreatic-Islets-pcbi.1005143.s003.ogv |
English: Phase plane animation of glycolytic oscillator recruitment and dependence on sinusoidal glucose signal period. An animated version of Fig 13. The glycolytic subsystem transitions between bistable and monostable as Ge oscillations cross the Hopf bifurcation at Gmid ≈ 14.5 mM. When bistable, a stable equilibrium is surrounded by an unstable limit cycle (dashed curve), which is surrounded by a stable limit cycle (solid black curve); when monostable, an unstable equilibrium is surrounded by a stable limit cycle. The state of the glycolytic subsystem, i.e. the phase point, trajectory (red curve) is trapped by rapid alternation between disappearance and re-emergence of the stable equilibrium’s domain of attraction (shaded gray) when Ge oscillates with 1 min period (left) but not when when Ge oscillates with 5 min period (right). |
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Source | S1 Video from McKenna J, Dhumpa R, Mukhitov N, Roper M, Bertram R (2016). "Glucose Oscillations Can Activate an Endogenous Oscillator in Pancreatic Islets". PLOS Computational Biology. DOI:10.1371/journal.pcbi.1005143. PMID 27788129. PMC: 5082885. | ||
Author | McKenna J, Dhumpa R, Mukhitov N, Roper M, Bertram R | ||
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This file is licensed under the Creative Commons Attribution 4.0 International license.
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Date/Time | Thumbnail | Dimensions | User | Comment | |
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current | 12:30, 31 January 2017 | 36 s, 585 × 180 (6.61 MB) | Open Access Media Importer Bot (talk | contribs) | Automatically uploaded media file from Open Access source. Please report problems or suggestions here. |
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Short title | Phase plane animation of glycolytic oscillator recruitment and dependence on sinusoidal glucose signal period. |
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Author | McKenna J, Dhumpa R, Mukhitov N, Roper M, Bertram R |
Usage terms | http://creativecommons.org/licenses/by/4.0/ |
Image title | An animated version of Fig 13. The glycolytic subsystem transitions between bistable and monostable as Ge oscillations cross the Hopf bifurcation at Gmid ≈ 14.5 mM. When bistable, a stable equilibrium is surrounded by an unstable limit cycle (dashed curve), which is surrounded by a stable limit cycle (solid black curve); when monostable, an unstable equilibrium is surrounded by a stable limit cycle. The state of the glycolytic subsystem, i.e. the phase point, trajectory (red curve) is trapped by rapid alternation between disappearance and re-emergence of the stable equilibrium’s domain of attraction (shaded gray) when Ge oscillates with 1 min period (left) but not when when Ge oscillates with 5 min period (right). |
Software used | Xiph.Org libtheora 1.1 20090822 (Thusnelda) |
Date and time of digitizing | 2016-10 |