File:Glioblastoma-A-Pathogenic-Crosstalk-between-Tumor-Cells-and-Pericytes-pone.0101402.s015.ogv

English: GBM cells modify the contractility of pericytes plated on laminin-coated silicone substrates. The area occupied by Far-Red (magenta color) dextran+-U87 cells is delimited by the yellow dashed line (analogous to a graft/host margin). Tumor-flectopodia (white arrows) are associated with modifications of the wrinkling substrate (green arrowheads). Red arrows and red arrowheads indicate flectopodia extensions emanating from groups of GBM-cells, at progressively later times. The altered position of the yellow dashed-line shows the modification of the co-opting-tumor front (first and final positions are compared in the final video-frame). Yellow arrows indicate the difference in the pericyte wrinkling activity at the interacting front. Δtime: 10 minutes; time: 8 hours; rate: 3 fps.