File:Genetic-and-pharmacological-inhibition-of-calcineurin-corrects-the-BDNF-transport-defect-in-1756-6606-2-33-S1.ogv
Genetic-and-pharmacological-inhibition-of-calcineurin-corrects-the-BDNF-transport-defect-in-1756-6606-2-33-S1.ogv (Ogg Theora video file, length 4.8 s, 298 × 200 pixels, 568 kbps, file size: 335 KB)
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[edit]DescriptionGenetic-and-pharmacological-inhibition-of-calcineurin-corrects-the-BDNF-transport-defect-in-1756-6606-2-33-S1.ogv |
English: FK506 increases BDNF vesicular transport in rat cortical neurons expressing polyQ-huntingtin. Representative movies showing dynamics of BDNF-mCherry vesicles in neurites
from rat cortical neurons ectopically expressing the first 480 amino acids of huntingtin containing 68Q repeats (480-68Q, mutant). The upper movies shows DMSO treated neurons and the lower movies neurons treated with 1 µM FK506 during 30 min. For each movies, 6 randomly chosen vesicles were tracked and visualized as dots using ImageJ software. Videomicroscopy experiments were done as in Methods except that images were collected during 2 minutes at a frequency of 1 image/s with an acquisition time of 300 ms. Scale bar corresponds to 5 µm. |
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Date | |||
Source | Pineda J, Pardo R, Zala D, Yu H, Humbert S, Saudou F (2009). "Genetic and pharmacological inhibition of calcineurin corrects the BDNF transport defect in Huntington's disease". Molecular Brain. DOI:10.1186/1756-6606-2-33. PMID 19860865. PMC: 2776580. | ||
Author | Pineda J, Pardo R, Zala D, Yu H, Humbert S, Saudou F | ||
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This file is licensed under the Creative Commons Attribution 2.0 Generic license.
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Date/Time | Thumbnail | Dimensions | User | Comment | |
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current | 00:10, 20 November 2012 | 4.8 s, 298 × 200 (335 KB) | Open Access Media Importer Bot (talk | contribs) | Automatically uploaded media file from Open Access source. Please report problems or suggestions here. |
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Short title | Additional file 1 |
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Author | Pineda J, Pardo R, Zala D, Yu H, Humbert S, Saudou F |
Usage terms | http://creativecommons.org/licenses/by/2.0/ |
Image title | |
Software used | Xiph.Org libtheora 1.1 20090822 (Thusnelda) |
Date and time of digitizing | 2009 |