File:From-Principle-to-Practice-Bridging-the-Gap-in-Patient-Profiling-pone.0054728.s004.ogv

English: The effect of factor VIII product half-life on the dynamics of thrombin generation over time post administration of fVIII. Each unit of time (spanning 1900–1921) in the video represents 8 hours. Thrombin generating capacity was simulated by inputting a single subject's (H1 from Figure 4) factor levels into our mathematical model. The theoretical fVIII products used here have half-lives of 6, 12.2, 18 and 24 hours. By definition the 6 hour product decays much faster than products with longer half-lives and therefore the thrombin generating capacity of the 6 hour product declines fastest followed by the 12.2, 18 and 24 hour products.