File:ENU-induced-Mutation-in-the-DNA-binding-Domain-of-KLF3-Reveals-Important-Roles-for-KLF3-in-pgen.1003612.s012.ogv

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English: Abnormal motion of the inter-ventricular septum during the cardiac cycle in adult CH homozygous mice. Short axis view of the inter-ventricular septum, and right and left ventricles of a homozygous Klf3 gene trap mutant of the CH line (age 58 wk) obtained using micro-ultrasound. The septum is near the middle of the image with the visibly enlarged right ventricle on the left side, and the left ventricle on the right side. At the end of systole, the inter-ventricular septum suddenly deforms and bulges into the left ventricle. This is likely caused by right ventricular systole continuing after the end of left ventricular systole due to the marked enlargement in right ventricular size in the CH mutant. Similar anatomic and ultrasound defects were also observed in some adult homozygotes of the XS line.
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Source Movie S2 from Kelsey L, Flenniken A, Qu D, Funnell A, Pearson R, Zhou Y, Voronina I, Berberovic Z, Wood G, Newbigging S, Weiss E, Wong M, Quach I, Yeh S, Deshwar A, Scott I, McKerlie C, Henkelman M, Backx P, Simpson J, Osborne L, Rossant J, Crossley M, Bruneau B, Adamson S (2013). "ENU-induced Mutation in the DNA-binding Domain of KLF3 Reveals Important Roles for KLF3 in Cardiovascular Development and Function in Mice". PLOS Genetics. DOI:10.1371/journal.pgen.1003612. PMID 23874215. PMC: 3708807.
Author Kelsey L, Flenniken A, Qu D, Funnell A, Pearson R, Zhou Y, Voronina I, Berberovic Z, Wood G, Newbigging S, Weiss E, Wong M, Quach I, Yeh S, Deshwar A, Scott I, McKerlie C, Henkelman M, Backx P, Simpson J, Osborne L, Rossant J, Crossley M, Bruneau B, Adamson S
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Format Bitrate Download Status Encode time
VP9 720P 1.52 Mbps Completed 04:42, 25 August 2018 5.0 s
VP9 480P 779 kbps Completed 04:42, 25 August 2018 5.0 s
VP9 360P 417 kbps Completed 04:42, 25 August 2018 4.0 s
VP9 240P 215 kbps Completed 04:41, 25 August 2018 2.0 s
WebM 360P 538 kbps Completed 00:37, 30 July 2013 4.0 s
QuickTime 144p (MJPEG) 1.09 Mbps Completed 12:50, 23 October 2024 1.0 s

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