File:Cyclin-dependent kinase structure.pdf

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Cyclin-dependent kinase structure

Summary

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Description
English: Tertiary structure of human Cdk2, determined by X-ray crystallography. Like other protein kinases, Cdk2 is composed of two lobes: a smaller amino-terminal lobe (top) that is composed primarily of beta sheet and the PSTAIRE helix, and a large carboxy-terminal lobe (bottom) that is primarily made up of alpha helices. The ATP substrate is shown as a ball-and-stick model, located deep within the active-site cleft between the two lobes. The phosphates are oriented outward, toward the mouth of the cleft, which is blocked in this structure by the T-loop (highlighted in green). (PDB 1hck)[1]
Date
Source The Cell Cycle. Principles of Control.
Author David O Morgan

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© The copyright holder of this file allows anyone to use it for any purpose, provided that the copyright holder is properly attributed. Redistribution, derivative work, commercial use, and all other use is permitted.

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current02:12, 8 April 2020Thumbnail for version as of 02:12, 8 April 20201,350 × 1,500 (4.57 MB)Rob Hurt (talk | contribs)Uploaded a work by David O Morgan from The Cell Cycle. Principles of Control. with UploadWizard

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