File:Complexes-of-Neutralizing-and-Non-Neutralizing-Affinity-Matured-Fabs-with-a-Mimetic-of-the-Internal-pone.0078187.s002.ogv

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Complexes-of-Neutralizing-and-Non-Neutralizing-Affinity-Matured-Fabs-with-a-Mimetic-of-the-Internal-pone.0078187.s002.ogv ‎(Ogg Theora video file, length 14 s, 600 × 600 pixels, 2.79 Mbps, file size: 4.66 MB)

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English: Changes in the structure of the N-trimer induced by the antibody binding. The orientation of the N-trimer in the crystal structure of a six-helix bundle of gp41, shown in yellow (PDB code 1ENV, C-helices are shown in white) is used as a starting point. The morphing procedure is applied to the N-trimer from the 6-HB to adopt the orientation of the N-trimer in the complex with Fab 8062 that is used as the destination point (green). The corresponding trimer in the complex with Fab 8066 (shown in red) is used as a reference point. The N-trimers from three structures are superimposed using the Cα coordinates of a single N helix. The side chains are added stepwise as sticks of the corresponding colors.
Date
Source Movie S1 from Gustchina E, Li M, Ghirlando R, Schuck P, Louis J, Pierson J, Rao P, Subramaniam S, Gustchina A, Clore G, Wlodawer A (2013). "Complexes of Neutralizing and Non-Neutralizing Affinity Matured Fabs with a Mimetic of the Internal Trimeric Coiled-Coil of HIV-1 gp41". PLOS ONE. DOI:10.1371/journal.pone.0078187. PMID 24244293. PMC: 3820714.
Author Gustchina E, Li M, Ghirlando R, Schuck P, Louis J, Pierson J, Rao P, Subramaniam S, Gustchina A, Clore G, Wlodawer A
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current00:17, 22 November 201314 s, 600 × 600 (4.66 MB)Open Access Media Importer Bot (talk | contribs)Automatically uploaded media file from Open Access source. Please report problems or suggestions here.

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VP9 480P 844 kbps Completed 13:21, 22 August 2018 18 s
Streaming 480p (VP9) 845 kbps Completed 22:39, 24 January 2024 1.0 s
VP9 360P 440 kbps Completed 13:21, 22 August 2018 16 s
Streaming 360p (VP9) 441 kbps Completed 14:21, 2 February 2024 1.0 s
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WebM 360P 507 kbps Completed 00:19, 22 November 2013 12 s
Streaming 144p (MJPEG) 1.09 Mbps Completed 10:43, 2 November 2023 1.0 s

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