File:Complexes-of-Neutralizing-and-Non-Neutralizing-Affinity-Matured-Fabs-with-a-Mimetic-of-the-Internal-pone.0078187.s002.ogv
Complexes-of-Neutralizing-and-Non-Neutralizing-Affinity-Matured-Fabs-with-a-Mimetic-of-the-Internal-pone.0078187.s002.ogv (Ogg Theora video file, length 14 s, 600 × 600 pixels, 2.79 Mbps, file size: 4.66 MB)
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[edit]DescriptionComplexes-of-Neutralizing-and-Non-Neutralizing-Affinity-Matured-Fabs-with-a-Mimetic-of-the-Internal-pone.0078187.s002.ogv |
English: Changes in the structure of the N-trimer induced by the antibody binding. The orientation of the N-trimer in the crystal structure of a six-helix bundle of gp41, shown in yellow (PDB code 1ENV, C-helices are shown in white) is used as a starting point. The morphing procedure is applied to the N-trimer from the 6-HB to adopt the orientation of the N-trimer in the complex with Fab 8062 that is used as the destination point (green). The corresponding trimer in the complex with Fab 8066 (shown in red) is used as a reference point. The N-trimers from three structures are superimposed using the Cα coordinates of a single N helix. The side chains are added stepwise as sticks of the corresponding colors. |
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Source | Movie S1 from Gustchina E, Li M, Ghirlando R, Schuck P, Louis J, Pierson J, Rao P, Subramaniam S, Gustchina A, Clore G, Wlodawer A (2013). "Complexes of Neutralizing and Non-Neutralizing Affinity Matured Fabs with a Mimetic of the Internal Trimeric Coiled-Coil of HIV-1 gp41". PLOS ONE. DOI:10.1371/journal.pone.0078187. PMID 24244293. PMC: 3820714. | ||
Author | Gustchina E, Li M, Ghirlando R, Schuck P, Louis J, Pierson J, Rao P, Subramaniam S, Gustchina A, Clore G, Wlodawer A | ||
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current | 00:17, 22 November 2013 | 14 s, 600 × 600 (4.66 MB) | Open Access Media Importer Bot (talk | contribs) | Automatically uploaded media file from Open Access source. Please report problems or suggestions here. |
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Author | Gustchina E, Li M, Ghirlando R, Schuck P, Louis J, Pierson J, Rao P, Subramaniam S, Gustchina A, Clore G, Wlodawer A |
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Usage terms | http://creativecommons.org/publicdomain/zero/1.0/ |
Image title | Changes in the structure of the N-trimer induced by the antibody binding. The orientation of the N-trimer in the crystal structure of a six-helix bundle of gp41, shown in yellow (PDB code 1ENV, C-helices are shown in white) is used as a starting point. The morphing procedure is applied to the N-trimer from the 6-HB to adopt the orientation of the N-trimer in the complex with Fab 8062 that is used as the destination point (green). The corresponding trimer in the complex with Fab 8066 (shown in red) is used as a reference point. The N-trimers from three structures are superimposed using the C? coordinates of a single N helix. The side chains are added stepwise as sticks of the corresponding colors. |
Software used | Xiph.Org libtheora 1.1 20090822 (Thusnelda) |
Date and time of digitizing | 2013 |