File:Coarse-Grained-Molecular-Simulation-of-Epidermal-Growth-Factor-Receptor-Protein-Tyrosine-Kinase-pcbi.1003435.s005.ogv

English: Representative P-site binding simulation showing competition between active sites: view of activator active site. Close-up animation of the trajectory shown in Video S2 but in an orientation with the active site of the activator in view. The simulation begins with P-site-1148A of the receiver monomer binding to the active site of activator (at ∼5 sec), which is followed by its displacement by P-site-1045A (at ∼30 sec), continues with the displacement of P-site-1045A by P-site-1068A (at ∼50 sec), and ends with the binding of P-site-992A to the catalytic site of the receiver (last frame, see also Video S2).