File:Coarse-Grained-Molecular-Simulation-of-Epidermal-Growth-Factor-Receptor-Protein-Tyrosine-Kinase-pcbi.1003435.s004.ogv

English: Representative P-site binding simulation showing competition between active sites: view of receiver catalytic site. Close-up animation of the trajectory shown in Video S1 but with the pseudo atoms of the receiver PTK domain in each trajectory image aligned and shown in an orientation with the catalytic site of the receiver in view. The simulation begins with P-site-1148A of the receiver monomer binding to the active site of activator (at ∼5 sec, see also Video S3), which is followed by its displacement by P-site-1045A (at ∼30 sec), continues with the displacement of P-site-1045A by P-site-1068A (at ∼50 sec), and ends with the binding of P-site-992A to the catalytic site of the receiver (last frame).