File:Canine-CNGA3-Gene-Mutations-Provide-Novel-Insights-into-Human-Achromatopsia-Associated-pone.0138943.s005.ogv

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Original file (Ogg Theora video file, length 22 s, 886 × 720 pixels, 9.01 Mbps, file size: 23.86 MB)

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English: Video recording of the molecular dynamics trajectory of the hCNGA3-V630del mutant CLZ trimeric structure. All simulations were run with a temperature of 310 K fixed using Langevin dynamics and a pressure of 1.0 atmosphere using the Nose-Hoover Langevin piston pressure control. The V630del mutant exhibited rapid loss of the coiled-coil tertiary structure over the course of about 100 ns, with unfolding beginning at the C-terminus within 30 ns, followed by the N-terminus within 50 ns. After 100 ns, the tertiary structure is mostly lost, leaving an amalgam of helices and an average backbone RMSD of 9.09Å.
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Source S5 Fig from Tanaka N, Dutrow E, Miyadera K, Delemotte L, MacDermaid C, Reinstein S, Crumley W, Dixon C, Casal M, Klein M, Aguirre G, Tanaka J, Guziewicz K (2015). "Canine CNGA3 Gene Mutations Provide Novel Insights into Human Achromatopsia-Associated Channelopathies and Treatment". PLOS ONE. DOI:10.1371/journal.pone.0138943. PMID 26407004. PMC: 4583268.
Author Tanaka N, Dutrow E, Miyadera K, Delemotte L, MacDermaid C, Reinstein S, Crumley W, Dixon C, Casal M, Klein M, Aguirre G, Tanaka J, Guziewicz K
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Date/TimeThumbnailDimensionsUserComment
current02:02, 6 October 201522 s, 886 × 720 (23.86 MB)Open Access Media Importer Bot (talk | contribs)Automatically uploaded media file from Open Access source. Please report problems or suggestions here.

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Format Bitrate Download Status Encode time
VP9 720P 2.55 Mbps Completed 03:45, 21 August 2018 1 min 20 s
VP9 480P 1.28 Mbps Completed 03:45, 21 August 2018 1 min 4 s
VP9 360P 640 kbps Completed 03:45, 21 August 2018 57 s
VP9 240P 321 kbps Completed 03:45, 21 August 2018 33 s
WebM 360P 619 kbps Completed 02:02, 6 October 2015 17 s
QuickTime 144p (MJPEG) Not ready Unknown status

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