File:An-Intrinsically-Disordered-Region-of-the-Adenovirus-Capsid-Is-Implicated-in-Neutralization-by-pone.0061571.s004.ogv
An-Intrinsically-Disordered-Region-of-the-Adenovirus-Capsid-Is-Implicated-in-Neutralization-by-pone.0061571.s004.ogv (Ogg multiplexed audio/video file, Theora/Vorbis, length 37 s, 640 × 480 pixels, 2.36 Mbps overall, file size: 10.39 MB)
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[edit]DescriptionAn-Intrinsically-Disordered-Region-of-the-Adenovirus-Capsid-Is-Implicated-in-Neutralization-by-pone.0061571.s004.ogv |
English: MDFF simulation of defensin-sensitive HAdV chimera, Ad5.F35, in complex with defensin. The movie starts with coordinates for penton base (gold and white) and fiber (green) with three docked defensin monomers (red) surrounded by five hexon trimers (blue) at one adenovirus vertex. The cryoEM structure of the complex (magenta) is faded in and the view is changed to show the whole virion. In the final segment, MDFF frames from a 100-picosecond simulation show the flexible RGD-containing penton base loops (white) envelop the defensin molecules. The last frame shows the negatively charged fiber sequence (18-EDES-21), which is critical for defensin neutralization, in a sphere representation. |
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Source | Movie S1 from Flatt J, Kim R, Smith J, Nemerow G, Stewart P (2013). "An Intrinsically Disordered Region of the Adenovirus Capsid Is Implicated in Neutralization by Human Alpha Defensin 5". PLOS ONE. DOI:10.1371/journal.pone.0061571. PMC: 3631211. | ||
Author | Flatt J, Kim R, Smith J, Nemerow G, Stewart P | ||
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Date/Time | Thumbnail | Dimensions | User | Comment | |
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current | 00:30, 27 April 2013 | 37 s, 640 × 480 (10.39 MB) | Open Access Media Importer Bot (talk | contribs) | Automatically uploaded media file from Open Access source. Please report problems or suggestions here. |
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Author | Flatt J, Kim R, Smith J, Nemerow G, Stewart P |
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Usage terms | http://creativecommons.org/licenses/by/3.0/ |
Image title | MDFF simulation of defensin-sensitive HAdV chimera, Ad5.F35, in complex with defensin. The movie starts with coordinates for penton base (gold and white) and fiber (green) with three docked defensin monomers (red) surrounded by five hexon trimers (blue) at one adenovirus vertex. The cryoEM structure of the complex (magenta) is faded in and the view is changed to show the whole virion. In the final segment, MDFF frames from a 100-picosecond simulation show the flexible RGD-containing penton base loops (white) envelop the defensin molecules. The last frame shows the negatively charged fiber sequence (18-EDES-21), which is critical for defensin neutralization, in a sphere representation. |
Software used | |
Date and time of digitizing | 2013 |
Language | English |
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2013
application/ogg
40d9a490eb5f63269aee5a868a15db0545c9d7b8
10,898,546 byte
36.88634920634921 second
480 pixel
640 pixel
- Biophysical simulations
- Macromolecular assemblies
- Videos of bioinformatics
- Macromolecular structure analysis
- Macromolecular complex analysis
- Videos of protein structures
- Innate immunity
- Videos of viral structure
- Host-pathogen interactions
- Videos of computational chemistry
- Molecular dynamics simulation
- Media from PLOS ONE
- Adenoviridae