File:Amyloid--and-Proinflammatory-Cytokines-Utilize-a-Prion-Protein-Dependent-Pathway-to-Activate-NADPH-pone.0095995.s004.ogv
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Amyloid--and-Proinflammatory-Cytokines-Utilize-a-Prion-Protein-Dependent-Pathway-to-Activate-NADPH-pone.0095995.s004.ogv (Ogg Theora video file, length 15 s, 512 × 512 pixels, 53 kbps, file size: 97 KB)
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[edit]DescriptionAmyloid--and-Proinflammatory-Cytokines-Utilize-a-Prion-Protein-Dependent-Pathway-to-Activate-NADPH-pone.0095995.s004.ogv |
English: Reversal of TNFα-induced rods occurs rapidly upon washout of TNFα. Neurons were infected 48 h with adenovirus expressing cofilin(R21Q)-mRFP and treated with TNFα for 12 h. Medium was removed and replaced with fresh medium without TNFα. Images were taken every 2 min for 1 h. Rod disassembly often was accompanied by their retrograde transport, often segmenting into several smaller rods before finally disappearing close to the soma. |
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Source | Movie S2 from Walsh K, Minamide L, Kane S, Shaw A, Brown D, Pulford B, Zabel M, Lambeth J, Kuhn T, Bamburg J (2014). "Amyloid-? and Proinflammatory Cytokines Utilize a Prion Protein-Dependent Pathway to Activate NADPH Oxidase and Induce Cofilin-Actin Rods in Hippocampal Neurons". PLOS ONE. DOI:10.1371/journal.pone.0095995. PMID 24760020. PMC: 3997518. | ||
Author | Walsh K, Minamide L, Kane S, Shaw A, Brown D, Pulford B, Zabel M, Lambeth J, Kuhn T, Bamburg J | ||
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This file is licensed under the Creative Commons Attribution 4.0 International license.
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Date/Time | Thumbnail | Dimensions | User | Comment | |
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current | 14:07, 1 May 2014 | 15 s, 512 × 512 (97 KB) | Open Access Media Importer Bot (talk | contribs) | Automatically uploaded media file from Open Access source. Please report problems or suggestions here. | |
14:07, 1 May 2014 | 15 s, 512 × 512 (97 KB) | Open Access Media Importer Bot (talk | contribs) | Automatically uploaded media file from Open Access source. Please report problems or suggestions here. |
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Author | Walsh K, Minamide L, Kane S, Shaw A, Brown D, Pulford B, Zabel M, Lambeth J, Kuhn T, Bamburg J |
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Usage terms | http://creativecommons.org/licenses/by/4.0/ |
Image title | Reversal of TNF?-induced rods occurs rapidly upon washout of TNF?. Neurons were infected 48 h with adenovirus expressing cofilin(R21Q)-mRFP and treated with TNF? for 12 h. Medium was removed and replaced with fresh medium without TNF?. Images were taken every 2 min for 1 h. Rod disassembly often was accompanied by their retrograde transport, often segmenting into several smaller rods before finally disappearing close to the soma. |
Software used | Xiph.Org libtheora 1.1 20090822 (Thusnelda) |
Date and time of digitizing | 2014 |