File:A-phenanthrene-derived-PARP-inhibitor-is-an-extra-centrosomes-de-clustering-agent-exclusively-1471-2407-11-412-S1.ogv
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A-phenanthrene-derived-PARP-inhibitor-is-an-extra-centrosomes-de-clustering-agent-exclusively-1471-2407-11-412-S1.ogv (Ogg Theora video file, length 16 s, 428 × 428 pixels, 495 kbps, file size: 975 KB)
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[edit]DescriptionA-phenanthrene-derived-PARP-inhibitor-is-an-extra-centrosomes-de-clustering-agent-exclusively-1471-2407-11-412-S1.ogv |
English: Live confocal imaging of MDA-231 cell in mitosis in the presence of the phenanthridine PJ-34. Mitosis with scattered centrosomes ended by cell death in a randomly selected MDA-231 cell that was incubated for 18 hours with PJ-34 (20 μM) applied 24 hours after transfection by the indicated vectors, and then scanned over-night (approximately 15 hours) in the presence of PJ-34 by confocal microscope. Cells were transfected by vectors encoding for γ-tubulin-GFP (for labeling of centrosomes; green) and for histone H2B-RED (for labeling of chromosomes; red). |
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Source | Castiel A, Visochek L, Mittelman L, Dantzer F, Izraeli S, Cohen-Armon M (2011). "A phenanthrene derived PARP inhibitor is an extra-centrosomes de-clustering agent exclusively eradicating human cancer cells". BMC Cancer. DOI:10.1186/1471-2407-11-412. PMID 21943092. PMC: 3204305. | ||
Author | Castiel A, Visochek L, Mittelman L, Dantzer F, Izraeli S, Cohen-Armon M | ||
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![]() ![]() This file is licensed under the Creative Commons Attribution 2.0 Generic license.
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Date/Time | Thumbnail | Dimensions | User | Comment | |
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current | 23:03, 15 June 2013 | 16 s, 428 × 428 (975 KB) | Open Access Media Importer Bot (talk | contribs) | Automatically uploaded media file from Open Access source. Please report problems or suggestions here. |
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Short title | Additional file 1 |
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Author | Castiel A, Visochek L, Mittelman L, Dantzer F, Izraeli S, Cohen-Armon M |
Usage terms | http://creativecommons.org/licenses/by/2.0/ |
Image title | Live confocal imaging of MDA-231 cell in mitosis in the presence of the phenanthridine PJ-34. Mitosis with scattered centrosomes ended by cell death in a randomly selected MDA-231 cell that was incubated for 18 hours with PJ-34 (20 ?M) applied 24 hours after transfection by the indicated vectors, and then scanned over-night (approximately 15 hours) in the presence of PJ-34 by confocal microscope. Cells were transfected by vectors encoding for ?-tubulin-GFP (for labeling of centrosomes; green) and for histone H2B-RED (for labeling of chromosomes; red). |
Software used | Xiph.Org libtheora 1.1 20090822 (Thusnelda) |
Date and time of digitizing | 2011 |