File:A-conserved-MCM-single-stranded-DNA-binding-element-is-essential-for-replication-initiation-elife01993v002.ogv
From Wikimedia Commons, the free media repository
Jump to navigation
Jump to search
Size of this JPG preview of this OGG file: 351 × 599 pixels. Other resolutions: 140 × 239 pixels | 600 × 1,024 pixels.
Original file (Ogg Theora video file, length 3.2 s, 600 × 1,024 pixels, 616 kbps, file size: 238 KB)
File information
Structured data
Captions
Captions
Add a one-line explanation of what this file represents
Summary
[edit]DescriptionA-conserved-MCM-single-stranded-DNA-binding-element-is-essential-for-replication-initiation-elife01993v002.ogv |
English: Animation of a model for MCM to select the translocating strand during origin melting. Symmetric surfaces in different shades of green represent the two MCMN portions of a double hexamer. The dsDNA is first encircled by the MCM double hexamer. The dsDNA is driven toward the double hexamer interface by the dsDNA translocase activity of the AAA+ ATPase domains (not shown), which would be located above the light green surface and below the dark green surface. The dsDNA translocation creates strand separation where volume is available, enabling the MSSB to preferentially bind the strand with 5′→3′ clockwise polarity when viewed from the ATPase domain. Importantly, the MSSB-bound strand corresponds to the strand upon which the MCM helicase will translocate (magenta at top, cyan at bottom), as shown in Figure 7B, right panel.
DOI: https://dx.doi.org/10.7554/eLife.01993.024 |
||
Date | |||
Source | Video 2. from Froelich C, Kang S, Epling L, Bell S, Enemark E (2014). "A conserved MCM single-stranded DNA binding element is essential for replication initiation". eLife. DOI:10.7554/eLife.01993. PMID 24692448. PMC: 3970758. | ||
Author | Froelich C, Kang S, Epling L, Bell S, Enemark E | ||
Permission (Reusing this file) |
![]() ![]() This file is licensed under the Creative Commons Attribution 3.0 Unported license.
|
||
Provenance InfoField |
|
File history
Click on a date/time to view the file as it appeared at that time.
Date/Time | Thumbnail | Dimensions | User | Comment | |
---|---|---|---|---|---|
current | 16:13, 26 April 2014 | 3.2 s, 600 × 1,024 (238 KB) | Open Access Media Importer Bot (talk | contribs) | Automatically uploaded media file from Open Access source. Please report problems or suggestions here. |
You cannot overwrite this file.
File usage on Commons
There are no pages that use this file.
Transcode status
Update transcode statusMetadata
This file contains additional information such as Exif metadata which may have been added by the digital camera, scanner, or software program used to create or digitize it. If the file has been modified from its original state, some details such as the timestamp may not fully reflect those of the original file. The timestamp is only as accurate as the clock in the camera, and it may be completely wrong.
Short title | Animation of a model for MCM to select the translocating strand during origin melting. |
---|---|
Author | Froelich C, Kang S, Epling L, Bell S, Enemark E |
Usage terms | http://creativecommons.org/licenses/by/3.0/ |
Image title | Symmetric surfaces in different shades of green represent the two MCMN portions of a double hexamer. The dsDNA is first encircled by the MCM double hexamer. The dsDNA is driven toward the double hexamer interface by the dsDNA translocase activity of the AAA+ ATPase domains (not shown), which would be located above the light green surface and below the dark green surface. The dsDNA translocation creates strand separation where volume is available, enabling the MSSB to preferentially bind the strand with 5??3? clockwise polarity when viewed from the ATPase domain. Importantly, the MSSB-bound strand corresponds to the strand upon which the MCM helicase will translocate (magenta at top, cyan at bottom), as shown in Figure 7B, right panel.
DOI: http://dx.doi.org/10.7554/eLife.01993.024 |
Software used | Xiph.Org libtheora 1.1 20090822 (Thusnelda) |
Date and time of digitizing | 2014-04-01 |