File:A-Validated-Multiscale-In-Silico-Model-for-Mechano-sensitive-Tumour-Angiogenesis-and-Growth-pcbi.1005259.s019.ogv

English: Animation of the microvascular pressure and interstitial fluid velocity. Combined visualisation, as in S10 Video, of the microvascular pressure and the IFV using vectors, during a 40-day period of tumour growth. The transparent growing sphere corresponds to the tumour, with the centre-line of the vascular tree shown only. IFV increases smoothly within the tumour during the simulation, as a result of the space-varying IFP as shown in Fig 5. However, IFV peaks at some points, mainly in the vicinity of collapsing blood vessels of the original network. This is due to sudden pruning of highly perfused vessels that leads to the loss microvascular pressure balance, which dynamically changes the intravasation and extravasation of plasma/proteins in the vessels. This, subsequently, dramatically modifies the distribution of the IFP.