File:A-Validated-Multiscale-In-Silico-Model-for-Mechano-sensitive-Tumour-Angiogenesis-and-Growth-pcbi.1005259.s019.ogv
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[edit]DescriptionA-Validated-Multiscale-In-Silico-Model-for-Mechano-sensitive-Tumour-Angiogenesis-and-Growth-pcbi.1005259.s019.ogv |
English: Animation of the microvascular pressure and interstitial fluid velocity. Combined visualisation, as in S10 Video, of the microvascular pressure and the IFV using vectors, during a 40-day period of tumour growth. The transparent growing sphere corresponds to the tumour, with the centre-line of the vascular tree shown only. IFV increases smoothly within the tumour during the simulation, as a result of the space-varying IFP as shown in Fig 5. However, IFV peaks at some points, mainly in the vicinity of collapsing blood vessels of the original network. This is due to sudden pruning of highly perfused vessels that leads to the loss microvascular pressure balance, which dynamically changes the intravasation and extravasation of plasma/proteins in the vessels. This, subsequently, dramatically modifies the distribution of the IFP. |
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Source | S12 Video from Vavourakis V, Wijeratne P, Shipley R, Loizidou M, Stylianopoulos T, Hawkes D (2017). "A Validated Multiscale In-Silico Model for Mechano-sensitive Tumour Angiogenesis and Growth". PLOS Computational Biology. DOI:10.1371/journal.pcbi.1005259. PMID 28125582. PMC: 5268362. | ||
Author | Vavourakis V, Wijeratne P, Shipley R, Loizidou M, Stylianopoulos T, Hawkes D | ||
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![]() ![]() This file is licensed under the Creative Commons Attribution 4.0 International license.
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Date/Time | Thumbnail | Dimensions | User | Comment | |
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current | 22:47, 2 March 2017 | 12 s, 1,920 × 1,004 (9.17 MB) | Open Access Media Importer Bot (talk | contribs) | Automatically uploaded media file from Open Access source. Please report problems or suggestions here. |
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Short title | Animation of the microvascular pressure and interstitial fluid velocity. |
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Author | Vavourakis V, Wijeratne P, Shipley R, Loizidou M, Stylianopoulos T, Hawkes D |
Usage terms | http://creativecommons.org/licenses/by/4.0/ |
Image title | Combined visualisation, as in S10 Video, of the microvascular pressure and the IFV using vectors, during a 40-day period of tumour growth. The transparent growing sphere corresponds to the tumour, with the centre-line of the vascular tree shown only. IFV increases smoothly within the tumour during the simulation, as a result of the space-varying IFP as shown in Fig 5. However, IFV peaks at some points, mainly in the vicinity of collapsing blood vessels of the original network. This is due to sudden pruning of highly perfused vessels that leads to the loss microvascular pressure balance, which dynamically changes the intravasation and extravasation of plasma/proteins in the vessels. This, subsequently, dramatically modifies the distribution of the IFP. |
Software used | Xiph.Org libtheora 1.1 20090822 (Thusnelda) |
Date and time of digitizing | 2017-01 |
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9,613,591 byte
11.5713 second
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Categories:
- Videos of cardiovascular physiology
- Videos of developmental biology
- Angiogenesis
- Basic cancer research
- Neoplasm physiology
- Videos of cardiovascular anatomy
- Videos of blood vessels
- Videos of bodily fluids
- Interstitial fluid
- Videos of cell biology
- Extracellular matrix
- Videos of classical mechanics
- Damage mechanics