File:The model depicts a mechanistic linkage between muscle activation by WB-EMS-mediated resistance exercise and cancer cell death in advanced cancer disease.jpg

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English: The model depicts a mechanistic linkage between muscle activation by WB-EMS-mediated resistance exercise and cancer cell death in advanced cancer disease. The muscle-derived factors IL10, CXCL1 and CCL4 are, at least in part, responsible for the exercise-mediated upregulation of caspase 3 and 7 expression in cancer cells. This correlates with the enhanced cleavage of the caspase 3/7 substrate PARP. Once cleaved, PARP cannot repair DNA damage, leading to more DNA fragmentation and ultimately to increased cancer cell death.
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Source https://www.mdpi.com/2072-6694/13/15/3820
Author MDPI

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This file is licensed under the Creative Commons Attribution 4.0 International license.
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This file, which was originally posted to MDPI, was reviewed on 30 January 2024 by reviewer Taivo, who confirmed that it was available there under the stated license on that date.

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current18:01, 25 January 2024Thumbnail for version as of 18:01, 25 January 20241,080 × 633 (204 KB)AbchyZa22 (talk | contribs)Uploaded a work by MDPI from https://www.mdpi.com/2072-6694/13/15/3820 with UploadWizard

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