File:The endo-siRNA biogenesis pathway.jpg
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The_endo-siRNA_biogenesis_pathway.jpg (600 × 402 pixels, file size: 54 KB, MIME type: image/jpeg)
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DescriptionThe endo-siRNA biogenesis pathway.jpg |
English: The endo-siRNA biogenesis pathway. Hairpin siRNAs are transcribed and fold into a long hairpin, which is cleaved multiple times by Dicer. cis-siRNAs are derived from transcription on both strands of DNA, resulting in a two-strand dsRNA with perfect complimentarity. trans-siRNAs are derived from gene/pseudogene pairs from distant sites in the genome. Because of mutations in the pseudogene, complimentarity of the dsRNA is not perfect. hp-siRNAs have been found in mouse oocytes and ES cells. trans-siRNAs and cis-siRNAs have only been found in oocytes. Adapted from Babiarz et al., 2008. |
Date | Published May 31, 2009. |
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[1] Direct
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Author | Babiarz, J.E., and Blelloch R., Small RNAs – their biogenesis, regulation and function in embryonic stem cells (May 31, 2009), StemBook, ed. The Stem Cell Research Community, StemBook, doi/10.3824/stembook.1.47.1, http://www.stembook.org. |
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This file is licensed under the Creative Commons Attribution 3.0 Unported license.
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Date/Time | Thumbnail | Dimensions | User | Comment | |
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current | 18:44, 5 April 2013 | 600 × 402 (54 KB) | Smallbot (talk | contribs) | Uploading CC-BY images from the the StemBook http://www.stembook.org/ 35/173 |
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