File:The endo-siRNA biogenesis pathway.jpg

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English: The endo-siRNA biogenesis pathway. Hairpin siRNAs are transcribed and fold into a long hairpin, which is cleaved multiple times by Dicer. cis-siRNAs are derived from transcription on both strands of DNA, resulting in a two-strand dsRNA with perfect complimentarity. trans-siRNAs are derived from gene/pseudogene pairs from distant sites in the genome. Because of mutations in the pseudogene, complimentarity of the dsRNA is not perfect. hp-siRNAs have been found in mouse oocytes and ES cells. trans-siRNAs and cis-siRNAs have only been found in oocytes. Adapted from Babiarz et al., 2008.
Date Published May 31, 2009.
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StemBook Figure 3 The endo-siRNA biogenesis pathway

  • Babiarz, J.E., and Blelloch R., Small RNAs – their biogenesis, regulation and function in embryonic stem cells (May 31, 2009), StemBook, ed. The Stem Cell Research Community, StemBook, doi/10.3824/stembook.1.47.1, http://www.stembook.org.
Author Babiarz, J.E., and Blelloch R., Small RNAs – their biogenesis, regulation and function in embryonic stem cells (May 31, 2009), StemBook, ed. The Stem Cell Research Community, StemBook, doi/10.3824/stembook.1.47.1, http://www.stembook.org.
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