File:The Glowing Emptiness of an Alzheimer's Disease Patient.jpg
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Captions
Captions
Beta-amyloid plaque being covered by microglia and astrocytes in Alzheimer's brain
Summary[edit]
| Description |
English: How can an explosion of colour be so damaging? How can so much light turn into absolute darkness? This is the sad reality that floods the brains of our Alzheimer's patients. The massive accumulation of these beta-amyloid plaques is one of the main causes of this pathology. It seems paradoxical to think that something so beautiful, observed through the lens of a confocal microscope, can result in the greatest harm to dementia sufferers. But perhaps that glow does symbolise something else, because wherever a plaque is located, microglia and astrocytes will fight side by side to prevent its spread and extension, giving a glimmer of hope to those who fight against neurodegeneration day after day.
Image taken with reflection confocal and/or scanning spectral fluorescence microscope LEICA Stellaris 8. Objective: HCX PL APO 63x/1.30 Glyc W.D. 0.30 mm. Composite made from 43 Z-planes with LASX 3D software and post-processed with FIJI.
Español: ¿Cómo una explosión de color puede ser tan dañina? ¿Cómo tanta luz puede tornarse en la más absoluta oscuridad? Esta es la triste realidad que inunda el cerebro de nuestros pacientes de Alzheimer. El acúmulo masivo de estas placas de beta amiloide es uno de los principales causantes de esta patología. Parece paradójico pensar que, algo tan bello, observado a través de las lentes de un microscopio confocal, pueda resultar en el mayor de los perjuicios para los enfermos de demencia. Aunque quizás ese resplandor sí simbolice algo más, pues, allá donde se ubique una placa, microglía y astrocitos lucharán codo con codo por evitar su propagación y extensión, dando un hálito de esperanza a quienes combaten contra la neurodegeneración día tras día.
Imagen tomada con microscopio confocal de reflexión y/o de fluorescencia espectral de barrido LEICA Stellaris 8. Objetivo: HCX PL APO 63x/1.30 Glyc W.D. 0.30 mm. Composición hecha a partir de 43 planos en Z con software LASX 3D y procesada posteriormente con FIJI. |
| Date | |
| Source | Own work |
| Author | Nicocapelo |
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This file was uploaded as part of Wiki Science Competition 2023. |
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| Date/Time | Thumbnail | Dimensions | User | Comment | |
|---|---|---|---|---|---|
| current | 11:33, 29 November 2023 | | 1,800 × 1,800 (1.68 MB) | Nicocapelo (talk | contribs) | Uploaded own work with UploadWizard |
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