File:Structure and signaling mechanisms of the putative mouse testicular GSC niche..jpg

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English: (A). Sertoli cells (green-specialized domain contacting and supporting GSCs), blood vessel and perhaps other cellular and non-cellular components including myoid cells and basal membrane function as a niche to maintain GSCs (red), allowing germ cells (pink) outside the influence of the niche to differentiate. (B). Sertoli cell-produced GDNF can activate Src and Akt signaling in GSCs, thereby maintaining their self-renewal, while integrins rich in GSCs may help anchor GSCs to the basal membrane. Erm expressed in Sertoli cells can help maintain GSCs by regulating the GDNF signaling pathway or an unknown signal pathway.
Date Published September 30, 2008.
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StemBook Figure 4 Structure and signaling mechanisms of the putative mouse testicular GSC niche.

  • Xie T., Germline stem cell niches (September 30, 2008), StemBook, ed. The Stem Cell Research Community, StemBook, doi/10.3824/stembook.1.23.1, http://www.stembook.org.
Author Xie T., Germline stem cell niches (September 30, 2008), StemBook, ed. The Stem Cell Research Community, StemBook, doi/10.3824/stembook.1.23.1, http://www.stembook.org.
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current18:56, 5 April 2013Thumbnail for version as of 18:56, 5 April 2013700 × 348 (113 KB)Smallbot (talk | contribs)Uploading CC-BY images from the the StemBook http://www.stembook.org/ 104/173

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