File:Structure and signaling mechanisms of the Drosophila testicular GSC niche..jpg

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Structure_and_signaling_mechanisms_of_the_Drosophila_testicular_GSC_niche..jpg (700 × 330 pixels, file size: 125 KB, MIME type: image/jpeg)

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English: (A). Cap cells (green) and cyst progenitors (purple) function as a niche to maintain GSCs (red, green shade representing the niche influence), allowing germ cells (pink) outside the niche to differentiate. (B). Aging affects JAK-STAT signaling activity and E-cadherin expression. The Dpp/Gbb-mediated BMP signaling pathway represses expression of differentiation-promoting genes including bam, thereby maintaining GSC self-renewal, while the Upd-mediated JAK-STAT signaling pathway is necessary and sufficient for GSC self-renewal. E-cadherin-mediated cell adhesion is required for GSC anchorage and spindle orientation, while Zpg-containing gap junctions are required for GSC survival.
Date Published September 30, 2008.
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StemBook Figure 3 Structure and signaling mechanisms of the Drosophila testicular GSC niche.

  • Xie T., Germline stem cell niches (September 30, 2008), StemBook, ed. The Stem Cell Research Community, StemBook, doi/10.3824/stembook.1.23.1, http://www.stembook.org.
Author Xie T., Germline stem cell niches (September 30, 2008), StemBook, ed. The Stem Cell Research Community, StemBook, doi/10.3824/stembook.1.23.1, http://www.stembook.org.
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