File:Structure and signaling mechanisms of the C. elegans GSC niche..jpg

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Structure_and_signaling_mechanisms_of_the_C._elegans_GSC_niche..jpg ‎(650 × 297 pixels, file size: 77 KB, MIME type: image/jpeg)

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English: (A). The Distal tip cell (DTC, green) functions as a niche to maintain GSCs (red, green shade representing the niche influence), allowing germ cells (pink) outside the influence of the niche to differentiate. (B). Wnt signaling controls the niche formation, while DTC-expressing LAG-2/Delta can activate Notch signaling, maintain functions of FBF1 and FBF2 and repress functions of differentiation-promoting GLD genes to control GSC self-renewal.
Date Published September 30, 2008.
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StemBook Figure 1 Structure and signaling mechanisms of the C. elegans GSC niche.

  • Xie T., Germline stem cell niches (September 30, 2008), StemBook, ed. The Stem Cell Research Community, StemBook, doi/10.3824/stembook.1.23.1, http://www.stembook.org.
Author Xie T., Germline stem cell niches (September 30, 2008), StemBook, ed. The Stem Cell Research Community, StemBook, doi/10.3824/stembook.1.23.1, http://www.stembook.org.
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